The center role of cyclins/ NEED FOR A CYTOKINE UNIVERSTY

It is increasingly recognized that Cyclins are the ultimate effectors of health.  Yes the fascination with the DNA, its replication in cell division, its activities with RNA transcription which translate in protein formation, its very nature of keeping the the code of cellular destiny, all that is nice and dandy.   But beyond the genes, what will determine the state of your health, what makes live long, healthy or sick, what makes it happen, ARE THE STATE OF YOUR CYCLINS!
1.It is the cyclins that make you grow (growth factors)
2.It is the cyclins that control passage of stage to stage during  cell division  (the name CYCLIN-dependent Kinase-Cdk comes to mind..
3.It is the cyclins that makes obesity a disease
4.It is the that kick the kinase gene into motion
5.It is the cyclin that inhibit and promote...makes feminine or masculine...
6.It is the cyclins that kill post synaptic cell in Traumatic Brain Injury or strokes
7.It is the cyclins that call specific inflammatory cells to the theater of infection
8. It is the cyclins that determine the virulence or resistance (persitence of a cancer) of a cancer
9. It is through cyclin control that the NF-kB operates to insure survival and adaptation
10. It is through cyclins that some mutations occur, some genes are amplified or repressed and therefore entire pathways are affected,  and more importantly it is through the cyclins that some Receptors are desensitized!
It is through cyclins that Stem cells are stem cells!
It is through cyclins that old people look frail, their muscle hypotrophic!
when a cancer is uncontrollable such as melanoma and kidney cancer, give a cytokine ! (Interleukin-2 or Interferon!)
FOR MOST DEMENTIA TO DEVELOP! LOOK INTO THE CYTOKINS!

So with all this, it is surprising that we don't hear more about the Cyclins!
some are inhibitory, some are promoters, although they can belong to the same family
you die old or from infection because of the cytokines!
so it is a surprise that these no CYTOKINE UNIVERSITY!

HEAD IN THE SAND AGAIN, OR LOSS OF WHAT IS ESSENTIAL!