Intralesional Cytokine Therapy in Cutaneous Melanoma: A Call for Clinical Trials
In an exploratory study in patients with dermal and subdermal
metastatic melanoma, we explored the use of intra lesional therapy with
low-dose GM-CSF (500 µg once weekly). In case of failure to obtain a
complete response in 4 to 6 weeks, IL-2 was substituted (18 million
IU/wk).4 The results revealed that such intralesional therapy was well tolerated without major side effects.
Complete responses were obtained in patients with small lesions ranging in size from a few mm up to 1 cm regardless of whether these were primary, satellite, or in-transit metastases. However, none of the large sclerotic lesions responded to intralesional therapy with either cytokine. The complete responses were noted clinically and confirmed pathologically by rebiopsy of some of the injected sites at 6 to 8 weeks after cessation of the therapy, and showed absence of tumor cells and no mononuclear cell infiltrates."
How can we possibly go wrong????
to Diabetes mellitus
to simply getting old
the key role of Cytokine cannot be stressed enough
every time you experience muscle pains
or wake up with age related flaccid muscles, it is the the Cytokines...
every time with autoimmune disease you cannot put up weight, it is the Cytokine...
obesity would not be a disease without the Cytokines?
so when are we going to wake-up? and truly fight cancer with the Cytokines?