Showing posts with label BAX. Show all posts
Showing posts with label BAX. Show all posts

Friday, December 7, 2012


Cancer cure is through death of the cancer cell.  To date, the main way of death for the cancer cell
is through Caspase activation cascade.  In most cells, we know how the main way the activation of Caspase occurs.  That is Cytochrome C is naturally anchored at the membrane inside the Mitochondria. The Anchor is in fact a chemical bonding or attachment through electrons, like molecules do attach to each other.  We believe there, Cytochrome C is attached to a Cardiolipin which is part of the lipids of the membrane.  Just imagine another molecule showing up with a free electron, the free electron could attract and pull the one involved in the attachment and break free the Cytochrome C.  That Cytochrome C electron no longer attached comes out and activates the Caspase (mostly Caspase 9 which eventually activates members of its family) and there starts the Caspase its work to coagulate DNA and genes start breaking,  thus leading to cancer cell death.  One of the molecules that produce such disturbing free electrons is Arsenic Trioxide.  This delivery of free electrons by arsenic trioxide is not limited to the mitochondria.   It occurs through the cytosol (liquid milieu of the cell) disrupting many cellular pathways, delivering global intracellular disruption.  ( for those savvy people, do remember that the " breaking" of the anchor could be induced from outside the Mitochondrial membrane through the AKT or Bax effect- this is where Bcl-2 negative effect is the strongest ) arsenic trioxide

This global disruption has been established to treat Acute Promyelocytic Leukemia (APL)  (by the way, Chinese researchers lead the way on this one).  Frankly speaking, this "Global disruption"can be used in any cancer.  The problem is that it can occur in any cell, including our normal cells.  Giving caution to the amount you use because of a narrow safety index. 

Vitamin C and Microhydrin have also free electron, that is why they can cool down free radicals and therefore are called Anti-Oxydants . The free electrons of these compounds seem to add to those of Arsenic Trioxide to Increase toxicity to the cancer cell.   It is worth mentioning that, at the DNA level, these free electron break the strand, triggering our first law (activation of P53 and stoppage of cell cycle).

3 main problems

1. Good and bad pathways are stopped, mitigating the effects of global destruction.
2. (non selectivity) Good and bad cells are killed. This effect is worse in patients with poor reserve of free electron clearing molecules (Gluthatione based, Superoxide based and others).  (CAUTION TO EVERYONE)
3. Arsenic is hard to get rid of, and chronic exposure signs will result.

But frankly speaking, you can use this to kill any Cancer.  Research will continue at CRBCM no matter what!

Of Note: Use of this information outside of the topic discussed herein, is not endorsed by the CRBCM

Tuesday, October 23, 2012

We believe in the cure for Cancer:

People talk about a cure and skeptics balk!
But the cure is possible and actually exists already in every survivor who had a remote history of cancer.
Remember this, a cancer cell is full of messages encrypted in chemical messages when to grow, when to start aging and when to die.  Yes cancer cells have an internal message when to start apoptosis (self destruction).
It means you could tell it to start apoptosis and kill itself.  Our challenge is to know how to speak to a cell.
Research are starting to learn that language in what is now known as Target Therapy.  Cancer treatment is now becoming a Piano tune.  if you hit the right keys in a song and the cancer cell get it, it will find its way to self destruction.  We are at the early stage of this music, still learning it.  Hitting this key here and seeing what happens.  We are finding out that even tough cancers such as Melanoma, if you hit the BRAF key, things start happening.  In some lung cancers, if you hit the EGFR key, you start getting somewhere.  It is just a matter of time before we start asking to a cell, now time for an increase in BAX or Caspases, and self destruct.  The cell has some redundancy and networking to complicate the road to self destruction, but we still believe that with the right tune, cancer cells will dance to self destruction, and yes cure is within our reach!