IN THE UNITED STATES THE SCARCITY OF FUNDING HAS BECOME A HINDRANCE TO THE CURE PROMPTING THE AMERICAN CANCER SOCIETY TO LAUNCH A TELEVISION CAMPAIGN ASKING PEOPLE TO TAKE THIS CAUSE BACK TO THE STREET. THE AMERICAN CONGRESS IS SHACKLED IN DIVISIONS THAT HAVE NOW BECOME VISCERAL AND NONSENSICAL. AMERICA HAS LOST ITS DREAMERS AND THEREFORE ITS INSPIRING IDEALS. UNDER THE PRETENSE OF FINANCIAL PRUDENCE, DREAMS ARE ALLOWED TO DIE, CURE LET TO ESCAPE ONE MORE DAY, AND CANCER VICTIMS ARE LET TO DIE IN THE PROCESS! (WE NEED LINCOLN BACK!)
"LET'S GET LOUD" THE CANCER AGENCY ADVOCATES, AND THE CRBCM SUPPORTS THE MOVEMENT!
ANOTHER COMPONENT TO THE PROBLEM, WITH SCARCITY COME MORE POLITICAL FAVORS, MORE DISCRIMINATION AND DISPARITY IN GRANT ALLOCATIONS. THE CRBCM DOES NOT EXPECT ANYTHING AT PRESENT. THE IRS IS STILL FIGHTING US BY SHACKLING OUR 501 STATUS. SUPPRESSION OF MINORITY RESEARCH POTENTIAL COMES IN ALL UGLY FORMS! WE WILL NOT BACK DOWN UNTIL THEIR PLAY BECOME IRRELEVANT TO THE COURSE OF HISTORY! CPRIT HAS PLAYED FAVORITISM, LOOK WHERE THEY ARE...DO THE RIGHT THING PEOPLE, NO ONE HAS REACHED THE MOON BY FAULTY MATH BECAUSE NATURE IS WATCHING! AT THE CRBCM, THE FIGHT IS ON, WE ARE NOT GOING ANYWHERE AND STAY IN
THE GAME UNTIL OUR VOICE IS HEARD, UNTIL OUR ENEMIES BECOME IRRELEVANT AND UNTIL WE ARE ALLOWED TO RISE!
Showing posts with label cancer cure. Show all posts
Showing posts with label cancer cure. Show all posts
Thursday, April 4, 2013
Wednesday, February 27, 2013
PREVENTABLE CANCER DEATH, AND YOU CAN'T DO A THING! AND THIS IS TEXAS/ USA!
HOW DO YOU LOOK AT A MAN 2 YEARS BEFORE HIS PREVENTABLE CANCER DEATH, AND YOU CAN'T DO A THING! AND THIS IS TEXAS/ USA!
Just got off the phone with a wife of a man with stage IIIB Penile cancer. Their largest problem is not the cancer, but the lack of insurance and lack of money. He needs Cisplatin, a drug older than myself, but can't afford it. He has positive inguinal node but can't afford a consultation with the radiation therapy DR. What to do? As an Oncologist I am offering my service, but this is not going to save the man.
It is a time like this that challenges your soul, you just want to run from this misery of mind and hide!
It is a time like this that universal Insurance makes complete sense, but it will come too late for this one man!
If you can help, call our clinic 915-307- 3354! And it is not the only case, I also have this 38 year old woman with unresectable Angiosarcomas in the liver.... same story....call if you can help!
Just got off the phone with a wife of a man with stage IIIB Penile cancer. Their largest problem is not the cancer, but the lack of insurance and lack of money. He needs Cisplatin, a drug older than myself, but can't afford it. He has positive inguinal node but can't afford a consultation with the radiation therapy DR. What to do? As an Oncologist I am offering my service, but this is not going to save the man.
It is a time like this that challenges your soul, you just want to run from this misery of mind and hide!
It is a time like this that universal Insurance makes complete sense, but it will come too late for this one man!
If you can help, call our clinic 915-307- 3354! And it is not the only case, I also have this 38 year old woman with unresectable Angiosarcomas in the liver.... same story....call if you can help!
Saturday, January 19, 2013
THIRD LAW OF NATURE, NO PROLIFERATION AND CONCURRENT DIFFERENTIATION. HOW THIS LAW CAN BE USED FOR CANCER CURE
While the first and second law refer to the well being of the nucleus for protection of the cell division and its integrity, the 3rd law pertain to cell differentiation. Basically the first law say that if DNA is altered, cell need to be stopped to allow correction. And the powerful P53 Activation has been put in place for that. Significant alteration of DNA will send powerful signal to P53, cause itS activation, and lead to cell cycle arrest. This is where the power of Cisplatin based combinations reside. And sure enough, this the basis of the notion that strong repair system will weaken this type of drug. The all notion of Microsatellite Instability and its role in cancer is based on this law.
The 2nd law, is significant destruction of the scaffold of Mitosis, the Microtuble and all actinic or actinic like molecules which makes mitosis impossible should lead to cell destruction no matter what. The intergrity of this system of Microtubule and filament not only control the critical phases of Mitosis (Metaphase, Anaphase), it control the integrity of membrane but also the cytoskeleton and cell mobility. It is the nervous system of the cell and the control of various anchors. Organelles of the cell are not just free flowing in general, they are anchored to the Reticulum membrane most of the time (unless destined to Autophagia for cell preservation) and important Molecules involved in Apoptosis such as Cytochrome are attached to Mitochondrial membranes. Suffice is to say that major alteration to these line of proteins will bypass major Cytosol based protection including the Bcl-2. This is the strenghth base of Taxol and Ixabepilone. It is the explanation for neuropathy and cardiac toxicity of Adriamycin. It is partially the explanation of Q-T prolongation etc.
The 3rd law is more complex, cell differentiation should not go with full proliferation. Cell that are fully differentiated should not be multiplying like crazy. and for sure, we do not want hundred of livers, 3 brain or 99 lungs. Have wonder why Atypia goes along with cancer transformation. Well you have to lose differentiation to restart multiplying again! And the poorly differentiated, the worse the magnitude of cancer.
The story of differentiation goes like this:
All cells have the same genome. But based on their position, internal and external stimuli, they will go one way or the other to specialize in a certain function for tissue and organ specialty. The external stimuli could be a change of Oxygen content, Ph, or messages from your neighbor cells sending growth messages etc. Internal stimuli are cytokines, morphogens, growth factors and signaling molecules or intracellular particulates. These will stimulate Receptors or pathways (such as the NF-kB) and cause genetic and epigenetic consequences in the Nucleus. Expression of genes which the cell want and need to be specialized will be achieved through heavy duty transcription of genes. On the other hand, to control the uniqueness of the tissue, epigenetic closure of multiplying capability genes is first completed to seal the deal on the fate of the cell. Differentiation is like an EXIT door. you can enter, but don't try coming back. And once you enter, immediately you are taking care by the transcription machinery directing you to where you should be going and you lose multiplication ability. The door however is not fully irreversibly closed. In cancer the flow of force reverse and instead of moving forward, the door is reopen and the differentiation machinery is reversed or disabled (poor differentiation), the door is reopen, and the cell start to multiply again as part of the cancerous process. Studies of Estrogen effect Vs Progesterone has shed some light in this case. When one look at estrogen, it has more effect on the Exit door, constantly pushing that door toward Multiplication than Progesterone that has little effect of the door but with similar effect on the terminal differentiation. Making Estrogen more cancer inducing than progesterone. Yes taking Estrogen gives you the relief of symptoms but it is the push toward reversing the Exit door flow (toward proliferation transcription) that is the problem!
Is expression of H3K or FG2 the markers of Exit door tinkering, we are working hard to determine this.
AS ONE LOOK AT THIS FLOW TOWARD DIFFERENTIATION, A SLEW OF THERAPEUTIC TARGETS EMERGE, THE ARRAY GOES FROM :
1. NEIGHBOR MESSAGES
2. ENVIRONMENT CHANGES
3. BLOCKING RECEPTOR UPSTREAM THE NF-kB AND COMPARABLE PATHWAYS
4. BLOCKING THE PATHWAYS
5. SEALING THE DOOR
6. METHYLATION OF GENES, AND PARALYZING OR MODULATING ENZYMES INVOLVED IN EPIGENETIC CHANGES (PCAF, p300 MAY BE)
7. BLOCKING TRANSCRIPTION MACHINERY, EXPRESSION OR GENES DIRECTLY.
CERTAINLY, SIGNS OF RESUMPTION IN ACTIVITY OF GENES MEANT FOR PROLIFERATION IS AN EARLY SIGN OF CANCEROUS TRANSFORMATION, AND The BEST WAY TO DETERMINE THAT A DRUG IS CANCER PRODUCING.
AS A MATTER OF FACT, THIS IS HOW PAMIDRONATE AND OTHER BIPHOSPHONATE ACT TO CONTROL CANCER, BY INCREASING DIFFERENTIATION AND RELIEVING PRESSURE ON THE EXIT DOOR.
WELL DIFFERENTIATED TUMORS WILL HAVE A BETTER PROGNOSIS BECAUSE THEIR GENERAL FLOW OF FORCE IS STILL TOWARD DIFFERENTIATION AND NOT THROUGH THE PROLIFERATION DOOR .
WE ARE WORKING HARD AT CRBCM!
The 2nd law, is significant destruction of the scaffold of Mitosis, the Microtuble and all actinic or actinic like molecules which makes mitosis impossible should lead to cell destruction no matter what. The intergrity of this system of Microtubule and filament not only control the critical phases of Mitosis (Metaphase, Anaphase), it control the integrity of membrane but also the cytoskeleton and cell mobility. It is the nervous system of the cell and the control of various anchors. Organelles of the cell are not just free flowing in general, they are anchored to the Reticulum membrane most of the time (unless destined to Autophagia for cell preservation) and important Molecules involved in Apoptosis such as Cytochrome are attached to Mitochondrial membranes. Suffice is to say that major alteration to these line of proteins will bypass major Cytosol based protection including the Bcl-2. This is the strenghth base of Taxol and Ixabepilone. It is the explanation for neuropathy and cardiac toxicity of Adriamycin. It is partially the explanation of Q-T prolongation etc.
The 3rd law is more complex, cell differentiation should not go with full proliferation. Cell that are fully differentiated should not be multiplying like crazy. and for sure, we do not want hundred of livers, 3 brain or 99 lungs. Have wonder why Atypia goes along with cancer transformation. Well you have to lose differentiation to restart multiplying again! And the poorly differentiated, the worse the magnitude of cancer.
The story of differentiation goes like this:
All cells have the same genome. But based on their position, internal and external stimuli, they will go one way or the other to specialize in a certain function for tissue and organ specialty. The external stimuli could be a change of Oxygen content, Ph, or messages from your neighbor cells sending growth messages etc. Internal stimuli are cytokines, morphogens, growth factors and signaling molecules or intracellular particulates. These will stimulate Receptors or pathways (such as the NF-kB) and cause genetic and epigenetic consequences in the Nucleus. Expression of genes which the cell want and need to be specialized will be achieved through heavy duty transcription of genes. On the other hand, to control the uniqueness of the tissue, epigenetic closure of multiplying capability genes is first completed to seal the deal on the fate of the cell. Differentiation is like an EXIT door. you can enter, but don't try coming back. And once you enter, immediately you are taking care by the transcription machinery directing you to where you should be going and you lose multiplication ability. The door however is not fully irreversibly closed. In cancer the flow of force reverse and instead of moving forward, the door is reopen and the differentiation machinery is reversed or disabled (poor differentiation), the door is reopen, and the cell start to multiply again as part of the cancerous process. Studies of Estrogen effect Vs Progesterone has shed some light in this case. When one look at estrogen, it has more effect on the Exit door, constantly pushing that door toward Multiplication than Progesterone that has little effect of the door but with similar effect on the terminal differentiation. Making Estrogen more cancer inducing than progesterone. Yes taking Estrogen gives you the relief of symptoms but it is the push toward reversing the Exit door flow (toward proliferation transcription) that is the problem!
Is expression of H3K or FG2 the markers of Exit door tinkering, we are working hard to determine this.
AS ONE LOOK AT THIS FLOW TOWARD DIFFERENTIATION, A SLEW OF THERAPEUTIC TARGETS EMERGE, THE ARRAY GOES FROM :
1. NEIGHBOR MESSAGES
2. ENVIRONMENT CHANGES
3. BLOCKING RECEPTOR UPSTREAM THE NF-kB AND COMPARABLE PATHWAYS
4. BLOCKING THE PATHWAYS
5. SEALING THE DOOR
6. METHYLATION OF GENES, AND PARALYZING OR MODULATING ENZYMES INVOLVED IN EPIGENETIC CHANGES (PCAF, p300 MAY BE)
7. BLOCKING TRANSCRIPTION MACHINERY, EXPRESSION OR GENES DIRECTLY.
CERTAINLY, SIGNS OF RESUMPTION IN ACTIVITY OF GENES MEANT FOR PROLIFERATION IS AN EARLY SIGN OF CANCEROUS TRANSFORMATION, AND The BEST WAY TO DETERMINE THAT A DRUG IS CANCER PRODUCING.
AS A MATTER OF FACT, THIS IS HOW PAMIDRONATE AND OTHER BIPHOSPHONATE ACT TO CONTROL CANCER, BY INCREASING DIFFERENTIATION AND RELIEVING PRESSURE ON THE EXIT DOOR.
WELL DIFFERENTIATED TUMORS WILL HAVE A BETTER PROGNOSIS BECAUSE THEIR GENERAL FLOW OF FORCE IS STILL TOWARD DIFFERENTIATION AND NOT THROUGH THE PROLIFERATION DOOR .
WE ARE WORKING HARD AT CRBCM!
Tuesday, October 23, 2012
We believe in the cure for Cancer:
People talk about a cure and skeptics balk!
But the cure is possible and actually exists already in every survivor who had a remote history of cancer.
Remember this, a cancer cell is full of messages encrypted in chemical messages when to grow, when to start aging and when to die. Yes cancer cells have an internal message when to start apoptosis (self destruction).
It means you could tell it to start apoptosis and kill itself. Our challenge is to know how to speak to a cell.
Research are starting to learn that language in what is now known as Target Therapy. Cancer treatment is now becoming a Piano tune. if you hit the right keys in a song and the cancer cell get it, it will find its way to self destruction. We are at the early stage of this music, still learning it. Hitting this key here and seeing what happens. We are finding out that even tough cancers such as Melanoma, if you hit the BRAF key, things start happening. In some lung cancers, if you hit the EGFR key, you start getting somewhere. It is just a matter of time before we start asking to a cell, now time for an increase in BAX or Caspases, and self destruct. The cell has some redundancy and networking to complicate the road to self destruction, but we still believe that with the right tune, cancer cells will dance to self destruction, and yes cure is within our reach!
But the cure is possible and actually exists already in every survivor who had a remote history of cancer.
Remember this, a cancer cell is full of messages encrypted in chemical messages when to grow, when to start aging and when to die. Yes cancer cells have an internal message when to start apoptosis (self destruction).
It means you could tell it to start apoptosis and kill itself. Our challenge is to know how to speak to a cell.
Research are starting to learn that language in what is now known as Target Therapy. Cancer treatment is now becoming a Piano tune. if you hit the right keys in a song and the cancer cell get it, it will find its way to self destruction. We are at the early stage of this music, still learning it. Hitting this key here and seeing what happens. We are finding out that even tough cancers such as Melanoma, if you hit the BRAF key, things start happening. In some lung cancers, if you hit the EGFR key, you start getting somewhere. It is just a matter of time before we start asking to a cell, now time for an increase in BAX or Caspases, and self destruct. The cell has some redundancy and networking to complicate the road to self destruction, but we still believe that with the right tune, cancer cells will dance to self destruction, and yes cure is within our reach!
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