More HYPOTHESIS FOR CANCER RESEARCH

Given what we know now, could intermittent use of Cipro and laxative (5 days every 6-8weeks) be the most effective prevention against Colorectal cancer?  The CRBCM is reviewing data to make this assumption. There is sufficient scientific data to suggest this is true and a larger clinical trial is warranted to assess this hypothesis.
Through the work of others, we now know that Ciprofloxacin has anti-topoisomerase activity.  That is comparable in its mechanism  to some powerful chemotherapy drug.   But compared to chemotherapy drugs, it has been used for longer periods safely.   It is not innocuous, nothing is, however, it has been used broadly and side effects denounced to date may all be reversible.  The major concern of such broad use of an antibiotic will be potential hematologic toxicity and bacterial resistance. This is to be balanced against prevention of a deadly disease (colorectal cancer).  Intermittent use could address some of these concerns.
Development of other safer mild anti-topoisomerase could result to avoid CIPRO use, and preserve it in our Antibiotic armamentarium.

It is now known that certain bacteria produce chemical molecules such as nitrates that affect the colonic epithelium.  And that the progression to Colon cancer is an evolutionary process, possibly this evolution to cancer cells is driven by chronic continuous irritation.  Cleaning intermittently the colon has been assumed to be good as it provides an interruption in these irritations.  It would make sense if the laxative follows the Cipro.

ADDING AN ANTI-PROSTAGLANDIN MAY HAVE ADDITIONAL EFFECT.

Given the fact that this may be controversial, it would make sense to have a broader discussion before implementing this idea. Tell me what you think!