focus on ETS gene

1.Could a combination of Thyroid and retinoic acid be effective in MDS under expressing ETS gene
Rascle et al :
" We show here that Myb-Ets inhibits both RAR and c-ErbA activities on specific hormone response elements in transient-expression assays. Moreover, Myb-Ets abrogates the inactivation of transcription factor AP-1 by RAR and T3R, another feature shared with v-ErbA. Myb-Ets also antagonizes the biological response of erythrocytic progenitor cells to retinoic acid and T3."

2. E26 amplified in P.Vera?
3.What is the effect of Jakafi on the ETS gene expression.
4.Blocking GAG-ETS interaction could prove a major intervention in Myeloproliferative disorders and viral multipliction


It all looks like that this ETS is a way of directing the cell to a more vigourous multiplication particularly in the neoplastic process and Viral Multiplication through amplification and interactions with regulatory GENES.  (don't ask me now where is the miRNA).  This gene is so effective in its work, human cell adopted it.
and the shameless HIV comes in and uses it through the ENV-POL-GAG as mentioned!