Wednesday, July 16, 2014

check your sources, Are we in the belly of the beast!

When you study Arterosclerosis
when you study Breast cancer
Molecular movement inside the cell is important
then you come across this:
"
On binding a ligand the protein and ligand are internalized. This internalization is independent of macropinocytosis and occurs by an actin dependent mechanism requiring the activation Src-family kinases, JNK and Rho-family GTPases.[29] Unlike macropinocytosis this process is not affected by inhibitors of phosphatidylinositol 3-kinase or Na+/H+ exchange.
CD36 ligands have also been shown to promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer.[30]
Recently, CD36 was linked to store-operated calcium flux, phospholipase A2 activation, and production of prostaglandin E2[31]"  wikipedia

this is about CD36


and you start thinking, am I in the belly of the Beast.


Research has shown!


                                                                         PERK
                                                                              !
                                                                              !
                                                                 Phosphorylate
                                                                              !
                                                                              !
                                       PABP(interaction)---elf4 (ternary complex) which activates IRES   (HnRNPC1)

                                                     CD36-------Glucose
                                                                   !
                                                                   !
                                                             Reinitiation of protein translation


then there is a GNC4
a general initiation factor
A general translation factor
ATF4
work to do!
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