Wednesday, July 9, 2014

Watched a Video on Vitamin D on Medscape

I am puzzled by a Video on Medscape on Vitamin D.  I did hope I will learn more about Vitamin D
I came out just as confused...and indeed more puzzled by this question than ever.  Now I wonder what is the background of the man...The most sobering is that he did not have an answer for us and in fact added to the controversy.  Whenever this happens, it points to not only we need to know more, but that the analysis on itself was superflous...The notion that Vitamin D help for cellular growth and kinetic was the most insightful, the rest was globally speculative at best.
Several aspects where not discussed and goes to fundamental questions we struggle with:
Vitamin D has a known membrane receptor and one needs to define
genes downstream this Receptor
what other receptors are modulated by Vitamin D particularly when used at high dose as it is now fashonable
why is it that Vitamin D deficiency is associated with Autoimmune disease
what is the effect of Vitamin D on genes at epigenetic Zone
What are the Cytokines involved in various states of Vitamin D presence
Can high exposure of Vitamin D affect Methylation of genes or Acetylation of Histones
Can that Acetylation or Methylation be permanent as to realy induce Neoplastic performance
At which doses these permanent genetic changes are actually induced
and what are the risks of chronic versus intermittent exposure to Vitamin
at which doses there could be a problem
and what gene (heterozygosity) predispositions the carrier to genetic insults
is there relation with the lipid receptors and genes
Is there relation with the Insulin Receptors and genes
Is there relation with genes at the epigenetic Zone,
ONLY STUDIES AT THESE LEVELS, ANSWERING AT LEAST HALF OF THESE QUESTIONS, DESERVE VIDEO BEING SELECTED FOR CONSUMPTION IN A MEDICAL MEDIA...

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