Until we can talk to the CBX, the piccolo, and the IKAROS, Brain tumors and certain Leukemia will remain elusive!

It is striking what similarities exist between brain tissue function and white blood cell function at the molecular level.  When it comes to Neoplasia, Medulloblastoma is linked to hematologic neoplasm!
And any therapeutic intervention against blood cell proliferative disorders may have Neurologic side effects, and it is important that Phase 1 studies be conducted in centers that can handle seizures and accurately evaluate mental status changes (Leucodystrophic Encephalopathy)!  The similarities are not only found at the membrane where the frizzled and the Lck, and Merlin (Neurofibromatosis) are located, but deep inside the cells at the Nuclear/Chromatin level where the Ikoros and CBX5 are plenty at play!
It is evident that the CBXs and the Ikoros are epigenetic and this is where Leukemia and most malignant Brain tumors come to hide their source and powers.  And guess who is following them, the triple negative breast cancers!  It is actually amazing that this last disease may be more likely Cytokine driven given its selective appearance in certain groups of our population (HLADRs implicated).
The CRBCM continues its unfettered progress, not distracted by belligerent political forces, but tracking down this disease from the Wnt, Notch, Wisp3, non expressed Hormone Receptors, to the STAT5, SMADs, and now to the SUV39H1-CBX, Ikoros, Piccolo,Tousled, a Ku70, and to chromatin modulation.
Progress is slow but deliberate.  It is surprising that even deep here, through the FADD-MBD4, the Caspases can help achieve Apoptosis...there is hope for the cure!