Thursday, November 28, 2013

Until we stop the bickering!

It is increasingly evident to us that the main obstacle to cancer cure is MAN.   The need for competitiveness, playing politics, pulling each other and egoism all affects where funds should go as we look at an evolving biologic phenomenon that is the living cell.   The attack and call for closure of our blog is just an example of such negative force that help the cure escape our grip.  Yes someone ill motivated has bombarded our blog with computer based viral attacks, electronically unsubscribed us from donor journal and memos, bug our applications to NIH, and spread venomous words about CRBCM to hinder our progress.  We are a "Coalition" meaning a corp of people ready to fight!  We will fight back with precision, deliberate fugue and determination because we believe that our cause is just and the right thing to be doing in this time of our lives.  The thing is people are still dying with cancers whether you like CRBCM or not.  And we believe in the cure!
The cure itself has undergone significant progress over time.  It was once believed that to be cured of cancer is to be totally free of cancerous cells.  But evidence has suggested that turning cancer into a "chronic" disease reduces mortality of the cancer to that level of mortality equivalent to or matching that of the normal population.  That is people with cancer may die from another conditions like anybody else!  That is equivalent to cure from cancer.  Cancer is bad because it causes Certain death within a short period of time.  Removing this notion is critical in our search for the cure!  In solid tumor, evidences have suggested that if you live more than 5 years, your chances of dying is close to a cure!  Bringing another new dimension to the notion of cure after cancer.   This 5 year survival notion does not apply to breast cancers, bringing to us another challenge to CRBCM.  Why is it that Breast cancer cannot go away after 5 years.  Our suspicion is that a wrong "consensus" has slipped into the mind of cancer cells.  They missed the message that they should go away and gene pathways such as the NOTCH may be involved!   Consensus pathways are not just limited to the NOTCH and all need to be explored!

The failure of Chemotherapy to achieve more that 20% of cures  has awaken us to the fact that an indiscriminate killing of cells is not the way to go.  We should have known this since even the history of the world has taught us this. New epidemic diseases never wiped the human race although they can cause significant mortality.  Man work hard to limit the casualties.  At cellular level, new challenges to the cancer cells are dealt with the same.  The cells are informed by dying cells about what is happening, they call their CDC organization and their CDC studies this new attack and prepare their answers, and there are already prepared old answers, but new answers are made up using the NF-kBs.  Those new answers are ultimately imprinted in the epigenetic zones of the cell.   Answers that have proven effective more than once are eventually imprinted in the DNA and are transmitted to daughter cells leading to the growth or adaptation of both layers of human immunity.

The advent of genetic based target therapy has proven to be a significant progression in our success in our fight for the cure.  Lessons learned from fighting inborn errors of metabolism has provided significant experience in the fight for the cure.  Gene interference techniques , replacement of missing molecules and adding down stream missing particles or enzymes have been successfully used to correct deficient pathways, leading to impressive response rates even in cancers that were notorious for killing their victims in a short times.  Metastatic Melanoma and pancreatic cancers are such venomous examples!
Today, in Melanoma expressing the Mutated BRAF overexpression, Vemurafenib and similar new agents have proven that inhibiting BRAFV600E leading to a change in the clinical evolution of these disease.  If anything has to be learned from the limited experience with these drugs, their effects appear ephemeral because we seem to ignore the importance of the "consensus message" that is inbred in the neoplastic transformation.
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