Thursday, January 23, 2014

BAD THINGS LOOK ALIKE, BUT TRY TO WALK WITH ME THROUGH THE MAZE OF GENES! LIGHT IS BORN!

AMBRY-GENETICS"
"Pancreatitis Panel includes concurrent full gene analysis for PRSS1, SPINK1 and CFTR. Pancreatitis Panel can detect 99% of PRSS1 and SPINK of known mutations and 97-98% of of CFTR mutations. Testing does not include CTRC gene analysis."

BUT DO YOU REMEMBER SPINK5
IN THE NETHERTON SYNDROME
WHERE THEY SPEAK OF ICHTHYOSIS AND LEKTI
AND STRATUM BASALE

AND PSORIASIS AND STRATUM BASALE, WHERE BASAL LIKE CELL COME FROM AND SEEN IN TRIPLE NEGATIVE BREAST CANCER,

REALLY LOOK IT UP, IN PSORIASIS THEY SPEAK OF CCHCRA1
WELL DOWNSTREAM THIS WE FIND POLR2C WHICH TALK TO TAF15 THEN SAFB WHICH ACTIVATES ESTROGEN RECEPTOR AND HNRPD WHICH INTERACTS WITH HSP27 AND LATER SPEAKS WITH TGFB AND PTPN12 AND BAMMMMM! IT REACHES BCAR1.   AND BRCA1 BECOMES FOUND IN TRIPLE NEGATIVE BREAST CANCER WHICH IS NOT FAR FROM PANCREATIC PROCESSES.     BUT IN ALL THE MAZE OF GENES OUR FOCUS REMAINS ON SP1, EP300,SIN3A,GATA1.

THE FACT REMAINS THAT TATA SPEAKS ALSO TO POLR2C, THE SAME POLR2C THAT SPEAKS TO TAF15.   HMMMM....AND TATA binding protein SPEAKS TO TAF15.

PTPN12 INTERACTS WITH SHC1 BUT WATCH IT ATTACKING SHC1 (REGULATOR OF APOPTOSIS) BECAUSE IT HAS THE FAMOUS SH2 DOMAIN LIKE A GAZILLION OF OTHER MOLECULE INCLUDING THE STATS AND THE JAKs.  YOU JUST DON'T KNOW WHAT YOU WILL TOUCH.

ON THE OTHER HAND UBIQUITICN C KEEPS ATTRACTING RESEARCHER FOR WHAT IT CAN DELIVER!  ONE NEEDS TO STRATEGIZE THIS APPROACH!
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