Vitamin has been defined as an organic molecule that our body needs but cannot synthetasize. It has got to be provided to our body through food. Today in age most vitamins have been synthetasized and can be sold to us as a pill at various concentrations. What is peculiar about vitamins, is that generally the body requires these Vitamins at very low amounts. The body has to seek these vitamins hungrily. Cells have to put out many ways of capturing these vitamin through gene receptors formation. This is the natural and balanced way of cellular life. The persistence lack of vitamins or their insufficiency have deleterious effects. In lung cancer, diets that are deficient in Vitamin C, A, and Beta Carotene have been reported to increase the risk this disease development, However heavy supply of Beta carotene to patient who have had lung cancer did worsen the prognosis because it induced higher risk of lung cancer. One should stop and wonder what the meaning of this fact is. Why is it that supply of a needed compound will be linked to deleterious consequences. The truth is that to any action there is a reaction!
The cell has no clear way of telling our body about its finite needs such as lack of vit D. It can only do things within the realm of its powers such as increasing its receptors in order to increase its chances to capture Vit D. This upregulation of receptors will have an impact on downstream pathways when of course the receptor ligand has been supplied particularly if it is provided abundantly! It is presumed that an exagerated supply of Vitamins may lead to Receptor desensitization at the long run. (to be continued)
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