One of the reality faced by cancer survivors is that they come to need hair treatments because the hair comes back but not the same. Cancer survivors most of the time report wrinkled hair. Treatment aimed at straightening the hair is often required. The Wnt is often involved in cancer, and most chemotherapy will affect it to be effective. Down the wnt pathway is the Frizzled gene which through the dishevelled gene will affect the the Axin maze of genes which could result on derangement of the AXIN (ACTIN).
If you can describe your hair as "disrupted", think first of the Frizzled and the Dishevelled gene"
wikipidia :"The frizzled (fz) locus of Drosophila coordinates the cytoskeletons of epidermal cells, producing a parallel array of cuticular hairs and bristles" There is some truth to that!
How this is linked to deeper disturbances is under intense research
remember this pathway involve the Wnt, a versatile gene that can follow canonical and non canonical pathways. Meaning it can reach the GSK-3B and therefore the Lef-TcF transcription gene or go non canonical on you and reach the MEKK/JNK with different peculiar downstream transformations.
Currently in Oncology practice, we do not pay attention enough to the resulting hair transformation. But it is there for us to see. Dismissing it as a potential message the body of the survivor is telling us...is totally missing the point!
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