To the survivors, Peace could come through the CENP-F, importin, EGF repeats! But we don't know what we know!

Yes it is true that when survivors of a cancer meet their Doctors, they look to him to tell them if the disease is back or if they should rest some more at peace.  The truth is that science has not work enough to provide good indicators of cancer recurrence particularly when it comes to those cancers missing standard markers.  For example if you follow a colon or ovarian cancer, the CEA and CA-125 will be respectively good markers to follow .  Most clinicians will do these tests serially,  and patient find comfort in following these related number of markers as their disease progresses.  The Marker's number help with decision to move forward with various therapeutic options before both the physician and the patient.  ie. if the PSA is increasing following a series of treatments, Prostate cancer will be supposed to progress or resist the said treatments, and often decision to change treatment will ensue.   On the other hand, Response to a treatment for metastatic prostate cancer will be judged based on how much it drops or decrease the PSA, a valid response criteria in Prostate Cancer.  So clearly, Bio-markers are here for us to be used in clinical practice.

However both the patient and their doctors remain silence when it comes to very dangerous cancers.  Sarcoma, Melanoma or even Brain cancers have no standardized Markers to follow.  It is sad to wait for the mass to grow in a convincing way to tell the patient that the tumor is on the move.  Often as we have our eyes on this tumor, somewhere else something happens to tell us the tumor is indeed on the move.  But one thing for sure, a tumor to grow need to multiply, use more proteins, its nucleus will tell us "I am at work more here" and we have ways to tell.  Mitosis and cell division is always in play when cancer Multiply and CENP-F will tell us,  Notch is in play and EGF repeats will tell the message (amplification of c-MYC will tell us), level of CSL genes will tell us NOTCH is hot or not!  level of Importin or BRAP- all these genes are at our disposal to tell something is up! And even level of Myosin and use of NLSs (Nuclear localization signals) can tell a story, but despite our big talk, we have not done enough to tell our patients the truth because those with means have not let us investigate these potentials to their fullest.  Researchers, the coalition want answers, in breast cancer, Wnt (CTNNB gene) and Notch (EGF repeats) are at work, when we sleep at the wheel.!  wake-up! The Nuclear localisation signals are winking at us, we don't wink back!