ABNORMAL HOMEOSTASIS, STOP LOOKING AT IT! THAT IS IF YOU WANT A DIFFERENT OUTCOME.

HAVE HAPPEN TO WONDER WHY SOUTHERN CHINA HAS A FORM OF NASOPHARYNGEAL CANCER, IS IT LINKED TO A PARTICULAR CLASS II MAJOR HISTOCOMPATIBILITY ANTIGENS, OR A PARTICULAR VIRUS RESERVOIR LOCAL TO THE AREA,OR IS THIS LINKED TO LOCAL FOOD ?

Have you wonder why some people will develop Osteonecrosis of the jaw while on biphosphonate, and why the jaw in particular, and why sometime after traumatic intervention, is the shear stress necessary to the pathophysiology of the events, is TNF and the NF-kB involved?

have you wonder why some patient on Phenytoin will develop gum hyperplasia ?

Events at the gene level is your answer, and don't sit there on research fund, we boast that we know the genes but yet we don't don't know events of these very days!  50 years from now, medicine of today will be completely obsolete. We keep looking at a comprehensive chemical panel as our ways of monitoring, looking at potassium level in the blood without knowing the status of related genes !  You and I know that for a normal K (potassium) level hormonal events are in play, kidney function, oral intake and other many components are also in play to maintain Homeostasis!
But do remember there is a right homeostasis where all components leading to it are functioning normally, there is also bad, unstable homeostasis, the abnormal Homeostasis that requires certain component to overwork to achieve such an homeostasis! ie Hyperparathyroidism secondary to renal failure but with normal calcium level...there are consequences to the high hormone maintaining a normal level reuired by homeostasis.  Why? because you realize that hormone is generated by a gene expression. that is the increased for hormone to be amplified, and gene is amplified.  A gene to be amplified some genes are repressed some where, and gene repression can start start something Neoplastic some where! ie PTEN repression!   Also Hormone are not fully specific to one receptor all the time, so there some unwarranted stimulation of some other pathways, and prolieration, evasion, and differentiation are triggered!

The point is we have 20% of people on dialysis dying every year for over a decade,  and we are there sleeping at wheels! our current monitoring is clearly inadequate.  We have no clue as to the status of the Notch and the Wnt in each individual, are we allowed to be surprise to observe a steady rate of sudden death in this population. And with their deaths, stops our observation...wake up people! fund research without politics!! put money where a difference will be made before other takes my message !  fund CRBCM! call 915-307-3354 and organizations such as us! Small but to the point!  Remember when you fund a University, only 20% percent of your funding goes to the true research, the rest is waste and overhead!  Check the budget of the MD Anderson, I am not kidding! fund CRBCM to get your money worth!