*There are more ALK positive agents available. They have ROS-1 Inhibition and some have ANTI-EGFR activity. Response in Brain tumor are noted. It is suggested that SOME of these agents work a little longer (in weeks!). YES most of these agents have wonderful response rates but not long lasting.
*In Glioma, Co-deletion of 1p and 19q announces response to chemotherapy. and Mutation in IDH gene is a good prognosis factor! (Isocitrate De-Hydrogenase). This Mutation is associated with the MGMT promoter of DNA methylation and G-CIMP,TP53, and ATRX. IDH1 mutation is mostly associated with Oligodendroglioma.
*Women with breast cancer which is ER positive not only will receive chemotherapy but now 10 years of Tamoxifen. Some reports suggested only 5% of them have a clear discussion of Fertility preservation issues
and fewer see a Reproductive Endocrinologist. Come ON Oncologists, wake-up and smell the coffee, the law is coming after you!
*Oral Topotecan is a good second line in Metastatic small cell lung cancer, could you add Avastin!? read David R Spigel et al!
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