Thursday, July 4, 2013

GENES in Pancreatic cancer

*The gene in pancreatic cancer
1.BRCA1, BRCA2,P16,
2.DPC4,
3.STK11/LKB1 (PART OF THE PEUTZ JEGHERS SYNDROME)
Serine/threonine kinase 11 (STK11) also known as liver kinase B1 (LKB1) or renal carcinoma antigen NY-REN-19 is a protein kinase that in humans is encoded by the STK11 gene.[1]WIKIPEDIA

4.KRAS "WHICH IS INTEGRATED IN THE SIGNALING PATHWAYS OF SEVERAL RECEPTOR KINASE INCLUDING EGFR AND THE INSULIN GROWTH FACTOR RECEPTOR-1
5.ATAXIA TELANGIECTASIA
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 Testosterone
 ESTROGEN
        !
COMPLEX                      !---------cAMPK------cell polarity and inhibition of abnormal morphology
-LBK1 +      -----------------!
-STRAD                           !----------CDC37 and HSP90 ----NFkB (MAPK)
-MO25                             !-----------SMARCA4-------------BRCA1 and P53

if you use this, please quote wikipedia and CRBCM for your own good!

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