We eat sugar to grow and get energy. Energy production occurs within the cell. How do sugars get into the cell? Mostly through a door opens and that one guy called "insulin" ! For insulin to work, it has to attach to a Receptor called "Insulin receptor". If enough sugar has entered and the cell has used the sugar it needs, it figures that we need to have an energy reserve, and makes fat for energy reserve. While doing the build up of fat, it also figures that we do not need so many doors for insulin to bring in more sugar...so it closes some doors or better, removes some of these insulin receptors (desensitization). The end result is that outside the cell, there is a relatively high number of Insulin Molecules. Well, without their regular doors/receptors the Insulin starts looking for other receptors to stimulate, and stimulation will occur at doors that look like Insulin, which unfortunately, once stimulated will go downstream and stimulate MAPK AND STRESS LIKE c-JUN/fos LEADING TO INCREASED CYTOKINES with Interferons and interleukins leading to diseases caused by Obesity! That's how a simple fact gets rapidly complicated at the cellular level!
THIS MAKES OBESITY A CONDITION OF PROFOUND ENDOCRINE AND CYTOKINE DISTURBANCES! A TRUE DISEASE STATE!
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