*Since HAART, there has been a decrease of Lymphoma and CNS Lymphoma but not that much for Burkitt Lymphoma suggesting different pathology pathways in these various lymphoproliferative disorder in AIDS!
*3 factors impact Lymphoma occurrence inAIDS pt :
lack of HAART, age and low level of CD4
*The protective effect of HAART comes from the immune restoration following HAART.
*Incidence of CNS lymphoma, 5.6 /1000
*patient with HIV who developed Lymphoma had higher IL6, IL10, and expression of CD30. High serum free light chains was also observed!
*c-MYC is related to Plamablastic Lymphoma
whereas CCR5 has low risk for lymphoma
and stromal cell derived factor-1 Mutation has a higher risk of Lymphoma.
*Lymphoma can happen at any CD4 count and T cell count whereas Burkitt tend to occur at relatively high CD4 count where as Immunoblastic lymphoma and CNS lumphoma seem to prefer lower CD4 (around 50 or less).
*Plasmablastic Lymphoma involving mostly the Oral cavity is EBV related and characterized by CD138 and VS38s.
and Keratinization differ it from Oral Carcinoma!
*Hodgkin disease alone does not make it AIDS per CDC!
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