10 RESEARCH QUESTIONS IN ORAL CANCERS AND MEDICINE!

1.Early detection of Oral cancer leads to 90% cure rates whereas lymph node involvement drops that rate to 50% and require combination therapy to be achieved"

Can MDM2 Mutation, decrease E-Cadherin depression, and c_MYC amplification be detected in Sample from Saliva, blood of heavy smoker?

Is RHOC gene mutation predict Node involvement, is WISP3 involved?

2.Can BMPR Mutation and avB3 Integrin (+ associated Metalloprotease) predict for Osteoporosis of the Jaw in patients on Biphosphonate

3.Can Asporidin bound to Nuclear Agent helps detect Metastatic disease In Oral cancers?   (Change in Asporidin increases its Binding of TGF to Increase destruction in Osteoarthritis, and TGF is the autocrine growth hormone in Metastatic disease

4.Using new Biomarkers in Autoimmune diseases, can we develop a Kit to detect Oral Ulcerations that will benefit for a short course of Prednisone?

5.Levels of Interferon-1 in Hairy Leukoplaquia? Why Immunodeficiency is linked to hairy Leukoplaquia Interferon-1 is linked to Immune dysregulation...

6.Cevimeline role in post Radiation "Sicca"

7. can Injection of Lubricin improve Temporo-Mandibular Arthritis

8.Genetic basis of Oral Ulcerations in Beta- blocker users?

9.Role of Androgen Receptors in the deposition of Melanin during the Use of hydroxychloroquin, Minocycline, Methyl dopa, Ketoconazole, and Cytoxan

10.Role of Syndecans in Gingival Hyperplasia (Syndecans bind Growth factor FGF) (Why Gingival Hyperplasia  in patient taking Phenytoins, Cyclosporin, Calcium channel blockers, disruption of genes involved in cellular polarity?)

AT CRBCM, RESEARCH IS OUR PRIORITY!