Thursday, August 29, 2013

NEED FOR BIOMARKERS

"Cardiovascular Autonomic Dysfunction Predicts Outcomes in Diabetes

Marlene Busko

OULU, FINLAND AND GYEONGGI-DO, SOUTH KOREA — Among patients with stable CAD and type 2 diabetes, measures of autonomic function--such as heart-rate recovery after exercise--may help predict the risk of short-term adverse cardiovascular events, a new study hints[1]. A second study reports that autonomic dysfunction is strongly linked with a greater risk of severe hypoglycemia in patients with type 2 diabetes[2]".(MEDSCAPE) GO TO ARTICLE FOR FULL INFORMATION.

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This article examplify what we are talking about
autonomic dysfunction is home to the Wnt, Notch,ion channel,  and related membrane
ions channel, NEDD4, and all the FAKs.  Best we can come with is Heart rate reovery after exercise for autonomic dysfunction monitoring...
Medical revolution is needed!!!!

Wikipedia
"E3 ubiquitin-protein ligase NEDD4 also known as neural precursor cell expressed developmentally down-regulated protein 4 (NEDD-4) is an enzyme that in humans is encoded by the NEDD4 gene.[1][2] NEDD4 has been shown to ubiquitinate and therefore down regulate the epithelial sodium channel in the collecting ducts of the kidneys, therefore opposing the actions of aldosterone and increasing salt excretion. In Liddle's Syndrome NEDD4 is unable to bind to the ENaC and uncontrolled natriuresis occurs."
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