Monday, August 19, 2013

Learning from Anal cancer

One of the cancer that exemplifies the importance of trauma and Viral or infectious influences, is surely the Anal cancer!  Globally decreasing, it remains increasing in those who continue to practice anal sex.   It is also associated with the irritation of infections (HIV, Herpes 16, Chlamydia Trachomatis, and Gonorrhea).  Occurrence of warts remains an intriguing aspect that need further examination as they most likely represent a disruption at Wnt (global disruption of adhesion molecule and sens of polarity) and the notch.  (proof of concept).  Most importantly, This disease seems to involve a strong disruption of the NF-kB and down the stream epigenetic disturbances and associated increase growth hormones (TGFs).  This perception is reenforced by the very low or rare Mutations of KRAS found in this disease, and the effectiveness or exclusive efficacy of Mitomycin, a drug which easily lead to Fibrosis of the lung (which is associated to cyclines/growth factor effect).  Stopping or reducing the infection intensity has proven effective in reducing per-cancerous (Intraepithelial Neoplasia) lesions by at least  half, leading to the recommendation of giving Quadrivalent HPV vaccine  to males at 11-12 years of age by the Advisory Committee on Immunization.

Let's quantify now the NF-kB and the Cytokines in this disease...It could be good for the patients!

?Role of Histone de-actylators?
?miRNA
Interferon and Etoposide better than Cisplatin-5FU alone?

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