Plethora of Agents in Refractory Myeloma

There is no hematologic disease with so many new active medications
If you give standard chemotherapy agents in this disease, you will be looked upon with strange eyes in this day in age!

If you treat without knowing Cytogenetic changes in plasma cell, shame on you they say

Patient has to classified as "High Risk (del 17p)"  Vs "standard risk"
                                  (Velcade needed absolutely) Vs  (possible REVLIMID-DEX)


For those with Relapsed or refractory, a plethora of choices

1.  Elotuzumab + Revlimid + DEX
2.  Elotuzumab  + Velcade  + DEX
3.  Carfilzomib + Dex
4.  Pomalidomide + Bortezomib + DEX

Despite this you still have new agents

1. ARRY-520
2.Daratumumab
3.Panobinostat
4.Ixazomib
to try!
(Vorinostat said to "disappointing")

(Medscape) go to talk for a full more reliable discussion!  None of the above should be used unless you recheck the info!