One thing is certain, autoimmune diseases affect Mesenchymal tisues, the tissues that are full of Fibroblast growth factor 23 or Phosphatonins. and we know that Phosphatonins "inhibit both renal tubular phosphate reabsorption and 1-alpha-hydroxylation of 25-hydroxycalciferol' (YU). This fact alone will justify low levels in blood of 1,25-dihydroxycalciferol. Following this assumption, of course the worse the disease the more likely the vitamin deficiency. Therefore Vitamin D levels could be a biomarker gauging the severity of the disease (prognostic).
It is clear that disturbance of Phosphorus could also contributes to other electrolytes inbalances, grossly increasing the risk level of arrhythmia and sudden death. Of course too much Vitamin D is not good for you either.
Aging and Autoimmune diseases are characterized by increased levels of cytokines, all of which can affects these Phosphatonins with deleterious impact on our systems! The levels of Vitamin D receptors could also be directly affected by gene suppression by silencing as a result of epigenetic changes that occurs with the slew of cytokins, and may be the cytokins have a promoter effect on the Phosphatonin gene (s). Proof of concept needed!
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