One thing is certain, women seem to live longer than men...There seem to be many more widows than widowers! If you look at statistics of elderly who live the longest, you are more likely to find women than men. It is easy to say that men live a more stressful life and therefore die sooner, but one may also want to look into the main difference between men and women. And the Androgen level comes quickly to mind!
Androgen and related receptors are part of "wild genes", that is their effect here involves many genes downstream.
When you look at the span of genes which interact with the Androgen gene, one is struck by the deep epigenetic distribution of their effects!
One particular interacting gene stands out:
"NCOA4 has been shown to interact with Peroxisome proliferator-activated receptor gamma[4] and Androgen receptor.[ "(wikipedia)
The involvement of the PPAR gamma point to weakness of Antigen presentation and therefore a weakness in our defense mechanism. This perhaps opens the door to understanding why men having sex with men still have the highest Kaposi Sarcoma burden? I believe we are onto something here! look this up! NCOA4, a new target indeed!
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