Saturday, August 24, 2013

FAK COULD THEREFORE BE PROPOSED (ALONG WITH METALLOPROTEASE) AS A BIOMARKER IN CANCERS!

WHEN A PROTEIN, A RECEPTOR, ADAMS, OR EVEN AN ANCHOR IS "DETACHED" FROM CELLULAR MEMBRANE, AN FREE EDGE REMAINS AT THE MEMBRANE AND COULD POTENTIALLY ENGAGE A SLEW OF MOLECULES.  WE HAVE TERMED THIS POTENTIAL A "CHELOID EFFECT" WHEN REPAIR GOES WRONG!  THE Wnt AND THE NOTCH BEING PHENOMENA AT THE MEMBRANE, WILL BE CLEARLY ENGAGED, AND THE Src, AND DOWN STREAM PATHWAYS COULD POTENTIALLY BE ENGAGED (THEY ARE OBVIOUSLY WHEN A RECEPTOR IS DETACHED).
THE AMOUNT OF MEMBRANE FREE EDGES DEPEND ON CELLULAR INTERACTIONS WITH STIMULI INDEPENDENT OF ITS NATURE.  THE MOLECULAR NATURE OF THIS FREE EDGE OBVIOUSLY WILL INTERACT WITH BYSTANDER AND NEIGHBORING MOLECULES.  THEREFORE A CELL UNDER CONSTANT STIMULATION BY IRRITANT IS A "SUSCEPTIBLE" TO POTENTIAL NEOPLASTIC TRANSFORMATION.  THE NUMBER OF FREE EDGES APPEAR TO HAVE TO CORRELATE WITH CELLULAR EXPOSURE, AND COULD THEREFORE BE AN IMPORTANT BIOMARKER OF CELLS INVOLVED WITH NEOPLASIA.  THIS OF COURSE WILL BE NON SPECIFIC, BUT ASSOCIATED WITH OTHER BIOMARKERS, COULD BE CLINICALLY USEFUL!

PROOF IS HERE!

Biomarkers: FAK autophosphorylation independently predicts recurrence of gastric cancer

Shreeya Nanda!
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