Tuesday, December 31, 2013

AN EXCITING HIDDEN PEARL in triple negative breast cancers.

Hidden beneath the mantle of "triple negative breast cancer", one wonder if there is still to be discovered a sensitivity to Estrogen to be unveiled and used for therapeutic intentions.  One thing for sure there no one but many triple negative breast cancers.  Nothing is always the same when it comes to cancer, There is always and always will be a caveat!  Because of the variety of genes and their isoforms, and the heterogeneity of not only the isoforms but also their mutations.  But for the inquisitive mind, the suspicion that Estrogen can still work is a legitimate inquiry.
That is until you meet the Glucanase, Pectinase, and Polygalaturonases.
Before you start to wonder what in hell these have to do with anything. Let remind ourselves That Estrogen to be important has to meet its receptor.  The Receptor is made mostly of Protein but never forget the GLYCAN moiety that covers it.  For a receptor function, a glycan must be present.  And remember it is this Glycan moiety that triggers immunity (Primary/innate immunity in particular).  Then come the Glucanases that the cell send in the extracellular matrix to destroy the described functionally important covers of receptor and thereby annihilating their (receptor) very existence (CELLULAR DESENSITIZATION MECHANISMS).

In other words the lack of a receptor can be because they are not present enough to be detected by our measurements,  But if you find Pectinases and glucanases, the receptors' absence is deeper or I should say more radical.
There is something peculiar about this radical way of shutting down receptor by destruction through the Glucanases, That is, it is carefully engineered genetically and lead to disturbance of target protein vesicular transport.  ie Estrogen will be hard to travel the cell and will eventually be whisked away for Lysosomal degradation and related ESTROGEN GENE production will be shut down through the miRNA (the gene DND1 is at play here) or through the RUNX1- (interplay with Nuclear Receptor co-repressor1).  But shutting down these genes at production level, triple negative breast cancer cells make sure giving specific hormones will not work.  The noted hormone transport is disrupted, and its destruction assured.

NOW IF YOU ARE STILL IN DOUBT OF THESE PRECEPTS, AND YOU SHOULD BE SINCE IF YOU HAVE THAT RESEARCH INCLINED MIND, JOIN THE CROWD.  AND CHANG FR ET AL...IS A GOOD READING!

CRBCM, ENCOURAGING INTUITIVE MINDS! AND TEASING YOUR BRAIN ALWAYS!

BY THE WAY YOU KNOW WHO KNOWS MORE ABOUT THE GLUCANASES ? BEER MAKERS OF COURSE, THEY FERMENT GLUCOSES ALL DAY!  SMOKERS USE GLUCANASES TO DESTROY QUIETLY THEIR RECEPTORS ALL DAY, LOOK IT UP I AM NOT KIDDING! 
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