Too little, too late!

In a living cell, things are constantly happening, nothing is still,  molecules are constantly cross talking
so to believe that lipid deposits from Arteriosclerosis is benign is foolish...the endothelial cell that is covered by this stuff is constantly under pressure and Cytokines are being produced that will come back to hunt us as we plant head in the sand!  When it comes to cholesterol build up "zero tolerance " should be our norm.  But we have no lipase to throw at it we have no easy solution, so we wait that the occlusion be  more that 75% to attempt something...by then Cytokines have done their deeds, irreversible damage may have been done to the blood vessel wall.  Could PGC 1, the master co-activator, have warned us of the real toll on our systesm? or is it the PPARy, the RAR, c-AMP?   What are the true genetic biomarkers of Arteriosclerosis (to be continued)