GENES IN MELANOMA

ERCC6
DDB2
POLH
RAD2
p16/CDKN2A, p14ARF
CDK4
MCIR
NRAS
BRAF
KIT
MITF
PTEN
GNAQ
GNA11
XPA
BRCA
miRNA

1.does amplification of Grb2 influence c-KIT biomarker function...or response to Imitanib/Dasatinib
is Mutation or amplification of Grb2 necessary to predict response to treatment.
2.what is the therapeutic, prognosis roles of Cytokines in triple negative breast cancers and Melanoma for that matter.  We know CyclinD is involved,  But are theyr other Cytokine, Status of Ornithin?  Polygluthamine, Melanine derivative?level of Ketoacids in both serum and Urine?