Each time we turn around, people rush to discourage CRBCM that this and that has been studied and therefore there is no point to revisit the question. It is a weakness to believe that when it comes to cancer biology, revisiting a topic at molecular level always unveil an interesting aspect that had remain hidden or overlooked. Surprises are everywhere, you just have to keep your eyes open and remain suspicious of the evident...The Retinoic Acid Receptor has been known for long time, but the story of ATRA in Promyelocytic Leukemia does not date that long. As a matter off fact the story of Targeting therapy is not that old. It took a second look with new technologies to uncover new aspect of the same story. For a sole Researcher, going it your way may pay big. Shackled in large institutions, you have to follow the direction of the chief! But on your own, just pick up and go, surprises are still awaiting! There are 25000 genes, each with its habits, reactions and adaptations that are not fully uncovered. To believe otherwise is foolish, work hard and keep at it! The CRBCM is on that path...we believe is the future! Passion will take us there!
I was just reading about Lung cancer and what pathological Biomarkers have entered standard therapy (EGFR, ALK, ROS-1,etc...). These are for therapy decision, is that means our patients have stopped their need to know about for early diagnosis, no! Is that means we don't want to know about prognosis? No...if you work in this area, just keep on plugging along, until those who doubt come to recognize they are short sighted...things are awaiting your discovery everywhere your mind and heart take you...just keep at it!
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