Wednesday, December 11, 2013

Interesting genetic concepts

* Immediately post brain trauma,  Blocking DISC1 --- GSK-3 INTERACTION
could affect post traumatic brain disorder.  I wonder if early administration of Cyclosporin can have this effect by affecting the NFAT pathway?

* In small cell, I wonder if the YWHAE and CDK5 should be the focus of our attention?   Definitively looking into the Noonan disease gene since it induces malformation.
Inhibitor of the CDK5 should be the focus since the experience with the Melanoma has brought light on these inhibitors (p16/CDK2A/CDK4)!

* Could Disturbance of DISC1 explain post Radiation syndrome or "chemo-Brain"?
* Could Cyclosporin and various interventions decrease post Radiation encephalopathy?

*Is there a surge in peripheral blood cytokines post Radiation as experienced in Traumatic brain injury? And what cytokine is being observed?

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