Wednesday, February 26, 2014

CSK random phosphorylation/related clinical questions

FYN
LCK
LYN
YES-1
HCK
Src
FRG
BLK
FRK


1.ATRA combined to Geevec as a way to break gleevec resistance?
2.disease with PDGF with STATs amplification could benefit from Gleevec if inhibition of Src is promoted
3.Could ATRA or the Piperazines (Gleevec) disrupt enough deployment of signal pathways to slow down a Cytokine storm (and TBI).
4.Could dampening of CRKL be used as a marker in CML
5.can ADAMs 17 be a biomarker of CML response or Myeloma response
6"PDGFR-beta is a key marker of hepatic stellate cell activation in the process of fibrogenesis."wikipedia

level of PDGFR in hepatoma?or Glioblastoma/ Nexavar activity linked to effect on PDGFR? 


JUST WATCH OUT WITH THESE Random PHOSPHORYLATION, IT IS HOW CASEIN INDUCES TRIPLE NEGATIVE 
BREAST CANCERS. 

JUST REMEMBER Src INFLUENCES PDGF INDUCED PHOSPHORYLATION OF STATs.
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