Help us fund the Testing of Biomarkers to define, monitor and better address OBESITY, A CONDITION OF PROFOUND ENDOCRINE AND CYTOKINE DISTURBANCES, a true state of DISEASE!

Testing  Biomarkers to define, monitor and better address OBESITY,  A CONDITION OF PROFOUND ENDOCRINE AND CYTOKINE DISTURBANCES, a true disease state

We want to establish new guidelines for monitoring obesity by finding specific biomarkers.  Following BMI, lipid profile and pushing diet and physical activity is clearly insufficient.  Blocking the central nervous system to force mental rejection of food is not the answer, either.

Obesity becomes a disease because of its high inflammatory state, determined by a relatively high level of Growth factor and Cytokines inducing major deleterious consequences on the muscle skeletal system through the activated NF-KB. 

In morbid obesity, RIP140 levels are down-regulated in visceral adipose tissue. The RIP 140 (also known as NRIP1) interacts with DAX1 which involves the COPS2,  SREBF1 (the bone modulator) and SF1 ("feminization" of obese individuals). (see literature) In breast cancer, RIP140 is involved in regulation of E2F1, an oncogene which discriminates between luminal and basal tumor types. RIP140 influences cancer phenotype and prognosis.^{. "}In addition, RIP140 has a role in inflammation, since it acts as a coactivator for NFkappaB/RelA-dependent cytokine gene expression. Lack of RIP140 leads to an inhibition of proinflammatory pathways in macrophages and RIP-140 modulation is part of cachexia induced by Tumors. 

Also, in a state of obesity, even outside the cell, there is a relatively large number of insulin molecules."
Without receptors to stimulate, they will go downstream and stimulate MAPK AND STRESS LIKE c-JUN/fos, LEADING TO INCREASED CYTOKINES  with Interferons and interleukins leading to diseases caused by obesity.