Monday, March 17, 2014

An interesting Target: The Cullins

" the F-box protein p45(SKP2) is required for S phase and forms stable complexes with p19(SKP1) and cyclin A-cyclin-dependent kinase (CDK)2." Lisztwan et al...he went on to say:"CUL-1, a member of the cullin family, and the ubiquitin-conjugating enzyme CDC34 as additional partners of p45(SKP2) in vivo."
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 IT IMPLIES THAT THE CULLINS INTERVENE IN
1.PROMOTION OF UBIQUITILATION THROUGH CONTROL OF REGULATORS
2.SPEED OF OCCURRENCE OF S-PHASE.
BY AFFECTING E2 OR E3 FUNCTION, THE CULLING MAY AFFECT ANY PROTEIN DEGRADATION THAT COULD EXTEND TO THE CYTOKINES AND CYCLINS! "This implies that most cullins may use a SKP1/F-box-independent pathway to facilitate protein degradation."
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XIONG ET AL "

Cullin 4 is said to cause " G1 cell cycle arrest and an increased protein level of the CDK inhibitor Dacapo." and said "E ligase"

TO BE CONTINUED: " WHY THE CULLINS"

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