Thursday, March 6, 2014

Questions in limited Area of knowledge, focus on Vitamin D

1.Does intake of high dose Vitamin D decrease sensitivity to Androgen
Meaning Could it help in Prostate cancer Prevention
2.could dimerization to Retinoid X receptor be a self limiting  event enough to preclude toxicity and limit activity of High dose Vit D.
3.Should patient being treated with Promyelocytic Leukemeia be precluded from taking Vit D since it interacts with both  ZBRB16 and the Retinoid X receptor
4.Is over expression of STAT1,RACK1 enough of  biomarkers for Interferon Activity
and could Vitamin D increases activity of Interferon when given sequencially?  Vit D given for 1 to 2 weeks before starting Interferon to stimulate the epigenetic terrain!
5.Should women with STAT1 Breast cancer over expression avoid or take Vit D after remission
could intake of Vitamin D impact BRCA1 expression?  Could Vitamin D precipitate or slowdown Breast cancer occurrence in patients known to have BRCA 1 positivity (could it be preventative ?)
6. key words by Researchers:

-Zhao et al: " We show that Bim is a direct target of E2F1 and that HDAC inhibition promotes the recruitment of E2F1 to the Bim promoter." as they explained HDAC inhibitor's apoptosis...

-What P73 a biomarker of?  Activity of P53, resistance to P53 inhibitor, or it is time to use a E2F1 inhibitor?

-Kitagawa et al:"Nutlin-3 is a selective inhibitor of the p53-Mdm2 interaction, and inhibits growth in most tumor cells with wild-type p53."

7.Can increase in IgM predict lymphoma recurrence?

8.Can P73, CD154,RNF128  mark recurrence of cancers?

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