Monday, May 2, 2016

Is the black hole evidence of the existence of parallel universe

We all agree that black hole exist, they suck universal objects such as planets and suns and moon
but for where....matters sucked will go where?
it is true that we started off as a big bang
or was it a big bang, did we come from the other side of a black hole?   in a parallel universe
is the big bang the explosion that follows from the furnaces of a black the black hole the origin of the dark natters that seem to offset the rules of Physics...indeed it has been calculated that in its tourbillon of a galaxy, matters should be moving faster while at the periphery things should going a lot slower ...but it is not thru as peripheral bodies of a Galaxy are like charged up by "dark" matter as they spin at exhilarating speed (?from black holes)  matters seems to foil the matter is Energy...may be by mixing with tangible matters at the periphery of Galaxies...but where things go after an absorption by black they just vanish or may be transformed in true black matters...or come  out the other side in a parallel universe?...if it is true that nothing is created all transform...where things go after passage through the black holes...?

Wednesday, April 27, 2016

The promises at CRBCM

Dear Dr. Kankonde,

We will forward the kits for HLA typing of his sibs.
I will inform our Cell and Gene therapy unit.


From Baylor University to CRBCM

2:42 PM (18 hours ago)

"Augmented Hyper-CVAD based on dose-Intensified Vincristine, Dexamethasone, and Asparaginase Therapy"  Katarjian et al...

This is what Baylor University has recommended for our patient with refractory ALL. (peristant MRD)  we thank them...

If all will end

According to most astrophysicists, the world will end in an explosion caused by comet that will be large enough to cause cataclysmic shifts how ever you can imagine them...but with all evidence this all could be avoided at least theoritically...because the velocity and masses of the incoming meteorite could be predicted years ahead, science should be ready to "deflate" the speed of the incoming and arrange for a "softer" landing.    Today we see vehicle sent to mars covered in Balloon to avoid a tough impact on Landing, why can't a comet be assured a soft unnatural  landing...on Balloons or after repeated deflagrations and deflations....we need to start thinking about this now and not accept the fate of the dinosaurs...In principle, all this is possible, if we know how to govern the forces already present in the Cosmos.    We know a ray of some sort can pulverize anything of in its a ray from a Pulsar, can we have such a ray...can we maximize laser to bombard incoming meteorites...don't just shoot down satellites...but sizable meteorites aimed at earth...that may breach our atmospheric layer of protection...should the human race be doomed because we played the victims by accepting the fate of our planets...the forces that led to our existence have designed us to dominate the Universe and Cosmos...they did not tell us how but it is in our souls, our minds to figure it out...Today we look upon the sky to see the distant sky...but we know we can one day "warp" through the interstellar like going to Walmart...The fact is earth itself is traveling around the Sun at thousands of miles just by using gravity toward the Sun...who say we cannot "sling shoot" into Cosmos inside a "Dirigeable"toward new worlds...It is for us to make this happen...our trip started with the comet that brought us to Earth...Let's not stop here!...

Tuesday, April 26, 2016

life a continuuum of things...B

The news from space is still coming in
it is new for me but certainly old for those who have been following it closely
it is a time striking  and at the same time soothing
striking that life was started by some kind of an explosion that caused creation of gamma rays
soothing that we are probably the extra-terresterial we have been looking for brought in by a comet...and that our composition is same as our sun, we can now relate...which soothes my heart...
the same information tells me about preliminary notion of quantum physics such as quantum enigma...
Delving into the minuscule after looking at the sun makes perfect sense because we all part of the same continuum...from the particules making the neutron to the macroscopic us and the sun to the making of cosmos ...It is in this context that we can understand the intricacies of genetics...and its causing of diseases such as cancers.   The notion that Helium is created constantly in our Sun through bombardement so to speak by activity of electrons, creates in effect matter elements similar to what we are made of at a rather more complex state but yet the same matter...similitude at molecular level explain our susceptibility...If our DNA has Cytosine in its composition for example, any compound which react easily with Cytosine, will have implication at DNA level...directly...(see how easily products in a cigarette smoke can act directly on DNA...)  this where the crux of the matter is as it goes back to...our simple component...similar to the Sun...
then goes this notion that different atoms have a symetrical atoms distant away and no matter what distance there is similarity in their activities (the doppelganger effect)...this goes deep...that any of us has a doppelganger... spooky in a way....but I believe it....what this tell us...

Tuesday, April 19, 2016

In cancers, It is remove the break and release!

Many cancers are allowed to occur when Breaks in genetic pathways are removed
and abnormal proteins are being released (or formed) as a result of failures.
Of course one of the way the gene acting as a break failure is through Mutations  (of course heterozygosity, missing or omission, or blockage will be the other ways of failing)...The failure is not alone...subsequent consequences result in the pathways leading to aberrations that ultimately engage the cancerous process.
These consequences end up amplifying a normal or abnormal gene (c-Myc) resulting in amplification of other genes in the pathways...and cancerous disease develop.   It is important to note that while this is happening, mechanisms to protect this dangerous development also are engaged...Mucus is formed to protect the cancer from detection (ie Colon cancer cells) and most importantly genes such as the PD-1/PDL-1 are also formed to hide the process even more deeply ...
say you want to check for Lynch Syndrome, you will find that the APC gene which is Mutated is not stopping the Wnt-signaling pathway which leads to "mutated proteins" or dysfunctional proteins which could block the Beta-Catenin from transcribing more resulting Oncogenes...This is an early event in the cancer development...making the cell loose the sens of containment and shape, a polyp will result...

Monday, April 18, 2016

Few GI update

*capecitabine with Avastin now a standard first line in elderly with Metastatic colorectal cancer
*S1 better then Gemzar in adjuvant setting in Pancreatic cancer
a drug that was for long time not available in the USA...
* and now what was suspected is now confirmed that Cisplatin-FU could be a second alternative to Mitomycin-5-FU as Radiation sensitizer for Anal Cancer...
*IN GE-junction Cancer, EGFR no
and Her-2 yes but with Trastuzumab (not Lapatinib)

Saturday, April 16, 2016

life, a continuum of structures

Life secret is hidden in several dimensions
distance among the suns and various planets, continuum of life structures, limitations of our minds, limitations in our lives etc...
I was talking to someone about how far is Orion, he tells me "I don't have to worry about this, I will never see it"...this attitude let the secret get a second wind...particularly at the time where "New Horizon probe is penetrating the intercelestial world beyond Neptune,  even scientists were lost  (lacking an objective for their probe)  until the new glacial object in this space became an objective for 2019.  In the same time, beyond the atome and electron, even smaller particules are being discovered  while we still don't know if our mountains, full of rocks, are "alive".   We can move while trees can't but they live longer than us...Methane is a proof of life on earth, but there is full of Methane on Titan a moon of Saturn, a planet which is still surrounded by moving "stones" which make this planet's belt and we recall our own history that earth too was surrounded by water and heavy stones that shielded the planet from sun rays and resulting cooling led to the disappearance of the seems like Saturn is still in that transition after being hit by a moon or a comet...we can still see the belt today...some speculate people from Saturn saw the comet coming and some may have mooved to Titan, therefore the Methane there...plenty of organisms may have survived there, those who can survive the cold...underwater...on Titan...aquatic life you see!   you have to go under the waters to meet them!...the methane is a proof of life...some speculate their membrane is not like our with bilayer lipid but "Methanic"... to sustain the cold...indeed they are so far away from the sun.  they get the sunlight but not the heat!   Beside there is time when they get eclipsed by Jupiter...the bigger planet...likely this is rare since these things spin around the sun at different speed...what an eclipse that must be...
In this world when we live less than a century...things have been happening for billions of years
so has to keep life secret beyond us...and trees which lives longer can,t tell us...can't write these things down to transfer the knowledge...our savants die off in the "flower" of their the deep mysteries of life untackled!...the mystery lives on...unimpaired!!!

Thursday, April 14, 2016

Research has restarted
This time with completion of our random selection of sera
Indeed 64 patients,friends and neighbors have volunteered their blood samples for for random gene mutation testing.  7 mutations were selected based on availability at UTEP  of Antisera.
c-Myc, Survivin, Cyclin B1, HCC-1, NPM1, P53, and p62 were randomly selected

We are Published!

In the Journal of Oncoimmunology
the article was submitted in Sept 2015
and peer reviewed in December 2015 when it was also Accepted
will be published under "original study"

"Serum MDM2 and Anti-c-MYC autoantibodies as Bio-markers in the early detection of Lung Cancer"
with DR Kankonde, and DR Zhang from UTEP
this will launch CRBCM as Center of genetic research!
The study was completed in established cancer patients
we need to run a similar study in smokers!
the challenge is on!

We cannot thank enough those who have made this research possible
1.MD Honors/World ONE London/UK,which provided initial fund
2.Tissue Bank, University of Virginia,Lung Cancer  Biospecimen Network!
3.Review Board at University of Texas at  El Paso
and DR Zhang team and in China DR Bao-Fa YU

Thank you a all lot!

Monday, April 11, 2016

Dark matter

one controversial matter in astro-physics is the existence of dark matter
but when you think about it, it seems to me that the existence of dark matter is evident
as there is a "no" for a "yes".   Evidences accumulate that increasingly well known phenomena may be explained by the existence of dark matter.   For those in the extreme, the moon circling around the earth is linked to the existence of "waves" of dark matter.   Any circling body around the sun may be driven by dark matter to not fall out. That force of attraction toward the earth center (pesanteur) is govern by dark matter.   one other not well publish fact is the center oriented fact when a light goes out in a dark room, luminosity goes out from periphery to the center (and never the other way) as dark matter moves in....The moon influence the oceans through activity of dark matter...For some the strength of dark matter is concentrated and represented by "Black holes" in Cosmos (while the force of "white matters" is represented by motion driven organisms...At the center of this line of two extremes are motion mess living such as trees...some wonder if rocks are also "living" in a philosophical way.

I come to think of it, if the rock was "living", it may make sense that there are so much rocks into the planets...

Monday, April 4, 2016

Chromosome Translocation, an old scientific curiosity

From Myelodysplasia to most cancers including T cell lymphoproliferative disorder, scientific readings continue to report how chromosomal translocations have such a prognosis meaning for our patients.   They go on to tell us how "breakable" these locations on the chromosome are...
"Loss of Heterozygosity (LOH) is identified in 30 to 60% commonly at 9p,10q, 1p, and 17p" cutaneous T cell Lymphomas  (Kuzel et al)
what most literatures does not report is just as important, but may be more important, is the specific gene really involved by the translocations.
for 5q deletion syndrome, a Myelodysplasia, the gene appears to have been discovered so that we can develop new Medicine aside from Revlimid, and may be understand a little more what induce the disease and what can be done more specifically...defining what a chromosomal deletion involves in terms of gene missing or criss-crossing appears more urgent now.

"Recently,RPS14 has been identified as a likely candidate gene involved in the 5q-syndrome" (ASCO)

Tuesday, March 29, 2016

Striking Facts

*Mutation of BRAF has been seen in all cases of Hairy cell Leukemia
Is that mean that Cladribine  and Pendostatin need to be used in BRAF positive Melanoma
or is this a different BRAF

The opposite is it true? should we use dabrafenib in Hairy cell Leukemia

Are they localized Mutations that differentiate the 2 types of BRAF Mutations...

*As it stands,  CLL treatment include
-Chlorambucil +/- Rituxan (or Ofatumumab/Obinutuzumab), R-CHOP
-Rituxan Bendamustine
-Idelalisib, the anti PI3K
- CARTs targeting CD19

Friday, March 25, 2016

Today's GIST

1. Standard treatment
is Imatinib for 3 years for patient with high risk of recurrence
those with Exon 11 in the KIT gene will respond the best

2.The 2nd line is Sunitinib
3.Those who resist these meds, well Regorafenib may work
check your FDA recommended list

More and capable Telescopes

when it comes to observing the Universe,  with our current means, comparison has been made that
we can only look from our stand points.   Briefly its like looking at a room from a "key Hole"
only more "Hobble Telescopes" are needed to look everywhere.   Let say the Batteries can also be improved to use Nuclear Batteries instead of the current which may last 30-40Years...More lasting Batteries are needed.
Same goes from genes, cellular Telescopes will be needed one day to map up the many interactions going on in the cell....

Thursday, March 24, 2016

Death Center

*There is nothing without substance
for smoke to exist there must be fire at origin
and since death is a phenomena, a death center must exist
so where is it in a human body
everyone including this author believe that it is in the Brain
It is irreversible, once launched or engaged.  No one survive it as if the "consensus" of all cells is to "remain dead" once the message is received.  One would speculate it could be in the lungs, however
hypoxia message needs to be received by the Brain for death to occur.
If you are falling from the sky or the skyscraper, you will be dead or unconscious prior to hitting the ground.  Once again your brain will give up first....
you can harvest any other organ but the brain so far...
The counter to this is now:  can we act directly on on the death center to avoid dying?
"are consensus genes" be considered involved in the death process.   Are people who live longer have mutations in the "consensus" genes.  Can we prove that intercellular communications  are involved in the death status.  Can we ultimately interfere with death?  block it for happening?   If really smoke assumes there is fire, the there are genes that directly cause a death state.   And if there are genes...

*With billions of suns in the Galaxy, it is almost impossible that there is no other life out there...
yet we will not know for one reason,  worlds are kept too far apart...the suns we can see (as stars) are too far away sometime 3 to 4 times the distance to our Sun.   No one can reach other sun's planet alive with our current vessels.   So we will not meet our cousins on other planets any time soon...but they are there wondering the same...denying their denying our own existence ...

Friday, March 18, 2016

Important Updates

*90 % of lymphoplasmacytic lymphoma have L265P
*Rituxan-EPOCH back into Burkitt lymphoma treatment
*the infamous S1 better than Gemzar in adjuvant treatment of resected Pancreatic cancers!
*BRAF Mutated colon cancer needs the famous "Kitchen sink" thrown to them-FOLFORINOX-Avastin

Wednesday, March 16, 2016

Lets back up a bit

It is hard to imagine that as you are reading this, you are indeed traveling at 63,000 miles around the Sun but it is true.  We should be dizzy but of course there are things that keep us from dizziness, our relation to Earth which is steady, the Atmosphere that enclosed us and keeps us safe and of course respectable distance of other planets and moons that although changing but at controllable speed.  Yes you look up the friendly sky and Orion is moving at slow eventually disappear for months that we can not see it...from one particular location at least...
But the Mystery of life goes on...suffice is to say that what we know of the Universe is not controversial but at least understandable...It is however progressing and always expanding.  New fact has come up to change our understanding...scientists had noted an object the size of a "moon" beyond Pluto...the object was visible for a while than it  disappeared.   But after a "while", the object came back then left again in sight...than it dawned on them that the object was rotating around some planet beyond pluto.  while Earth is turning around the Sun on an orbit that takes it 365 days to complete, This planet could take 1 million years to complete its orbit?  Is this true?  I guess we are lucky to have seen it...Suffice is to say that this is challenging our current understanding of the "Universe"...
Are there more planets beyond...I strongly believe so...until we intersect with another sun's planets and there are billions of suns in the Universe...In our own Galaxy-The Milky way, there are millions of suns...
That brings up the second question
Around each sun, there are planets
and if there are suns it means they produce energy for their planets and there must be planets that enjoy the same circumstances and condition as Earth,  meaning there must be life somewhere else as true as we exist!   However, don't expect them yet...we do not have the mean to reach anybody...don't look for life in some clusters...It is there in the Universe but so far away we can't reach it yet...
let's however reorient our search, find a sun and its planets, then locate the planet with the closest similarity with conditions on Earth and voila !   Here are our distant cousins!   watch out, they may not like us....Distance keeps us may die before reaching there with our current means...

The Universe secret is kept by the current distance to anything...the sun to Earth is 93,000,000 Miles
but the distance to some portion of Orion is 3-4 times that.   It takes 8 minutes for the sun ray to reach us, and close to half an our for Orion to become Visible...Ladies and gentlemen, you will die before reaching any of those worlds...

Friday, March 11, 2016

Views on Colon Cancer Prevention

The frequency of occurrence of Colorectal Cancers is attracting the attention of Researchers
It seems though that the occurrence of Cancer in the Colon seems to be linked
to an inflammatory process that get out of hands.   A Cytokine storm seems to be involved
in the process.   The proof is there.   Most anti-inflammation medications seems to reduce the frequency of cancer occurrence (Aspirin, in the latest study).
should we monitor the NFkB gene pathway and amplification in colon cancer
we should surmise that error in early diagnosis of certain inflammatory bowel disease (IBD) leads to Colon cancers.    Meaning that improvement into the diagnosis of inflammatory bowel diseases would reduce the frequency of this cancer.
should a CRP (C-Reactive Protein) be included in the screening of Colorectal cancers
should increase of IL4 help in prevention of colon cancer  (stimulation of CD124)
also follow TRAF genes and IKKs

In a way should we inject high dose of IL4 to prevent Colorectal cancers?
Is partial Colectomy at 50 a viable prevention mechanism for Colorectal cancer? (how about in those with family hx or elevated CRP with IBD)

"The benefit of Aspirin as a secondary prophylaxis in patients with resected Colorectal cancers appears to be linked to the presence of PIK3CA mutations (Liao)"

Wednesday, March 2, 2016

A second look

Can we disrupt this through the UPF-1
Nonsense-mediated mRNA decay (NMD) is a surveillance pathway that exists in all eukaryotes. Its main function is to reduce errors in gene expression by eliminating mRNA transcripts that contain premature stop codons.[1] Translation of these aberrant mRNAs could, in some cases, lead to deleterious gain-of-function or dominant-negative activity of the resulting proteins.[2]"

Can this have a major impact in Sarcoma?

Tuesday, March 1, 2016

It just follows therefore

It Just follow therefore that IDH-1 would be a Biomarker for use of
Temodar and 5-AZAcitadine or Decitabine for Gliobastoma
and may be adding Ifosfamide or Etoposide for Leukemia and sarcoma (Chondrosarcoma) that is positive for Mutant IDH-1.    (and wild type TET)

Monday, February 29, 2016

In life, All go in pathways

If you understands that life is hidden in pathways, you know half of the truth...and yes if you can touch A and B you may finally reach C and later on Z.   The price is really how much perspicacity you intend to put up....and how much surprises you intend to unveil!
The Brain is hidden in the skull, and lives of Oxygen and sugar (no transformation of fat here if any).  Therefore gene that intervene in Oxygenation and de-Oxygenation are critical.  A  little known gene called IDH-1 gene is important!
"The protein encoded by this gene is the NADP+-dependent isocitrate .... "Role of isocitrate dehydrogenase 1/2 (IDH 1/2) gene mutations in human tumors"."  wikipedia

This gene most found with the Mitochondria and probably the protosome intervene in the detoxification of the cell.  But why is this gene important in the all scheme of Brain cancer and leukemia.  The point is to ultimately find the connection of this gene with how much it is linked to expression of genes.  Indeed remember many gene messages are hidden by methylation.Well methylation is a phenomenon that is very NADP like or dependent phenomenon.   Therefore Methylation of genes within the Brain cell is very affected by IDH-1 gene mutation.   IDH-1 will involve Cytosine based molecules such as TET gene, the initiation point of Methylation/de-Methylation of genes...Just imagine if this happen in a Telomere (which affect aging)...the cell all of the sudden will have its   aging changed or tempered with.   This is happening in both Leukemia and Brain cancer...and may be certain Sarcomas.

Life is a continuum...Starting from particle before the atoms, How this is linked to planets and into the Universe remains a question that goes deep into the truth of life!

Temodar and 5 AZAcitidine works in these diseases...proof in the pudding....

Thursday, February 18, 2016

And it goes on

With millions of suns in our Gallaxy (the Milky way )chances are there could be
a earth like life comparable to ours.   But given the randomness of Circumstances that need to be met for our existence, the chance of finding other human beings remains remote.
Water, Oxygen and right composition of Oxygen based gazes need  to be gathered to lead to us like beings.
and why Dinosaurs did not return after the earth return to life,
because evolution occurs one way or the other given the circumstances?
So imagine one particular planet where Helium was the predominant gas,  the organism that will grow if any, may be the yellow man or green man that may result...or is it another dinosaur that will not survive even if we meet!   now come the question, should we meet at all?
I keep looking for now into Orion!

It gets complicated

from Myriad"Myriad’s newest companion diagnostic, myChoiceTM HRD, is an algorithmic measurement of three biomarkers associated with homologous recombination deficiency, combined with next-generation sequencing of the BRCA1 and BRCA2 genes in the tumor.  The three biomarkers, loss of heterozygosity (LOH), telomeric allelic imbalance (TAI), and large-scale state transitions (LST), have all been individually shown to be associated with BRCA1/2 deficiency.1"

Monday, February 15, 2016

Life Mysteries

Before you read this, take a moment to reflect about life as it is a mystery
Mystery in its being, extent, dimensions and even purpose ...The truth is in every which way
you look at it...the mystery of life goes on.
I was thinking about planets ...what is their purpose, are they "alive", why are they so many, do they still have some form life that we cannot define.
The distance to the sun, the distance between the planet, how far is "Pegasus" and the planets of Orion or Sirius etc...all this is measured in dimensions that are difficult to comprehend.  One thing is for sure, many have agreed that we are under the influence of the moon.  That our mood swings with it, that our ocean's wind changes with there a message we are unable to understand...Is there a "pulse" to earth or other planets.   We know something wakes up Volcanoes or earth quakes but we still don't know what (and how to predict) earth a living being?
One thing for sure not only we do not pay attention enough to things around us (It took me over 50 years to start my interest in the stars) but also the secrets or mysteries of life is kept by many things including our lifespan.   When we look at life at planet level, 100 years is meaningless...we die before we can actually learn enough...even the batteries on the hubble Telescope last may be 30 years...They will die before we discover more...our best minds such as Einstein perished before greater revelations were made.  The mystery is preserved because a continuum is broken each time a researcher dies!
Are we not replacing our researchers?  yes we are but do they have the same fervor and caliber...that we can debate...the same goes when we look into genes,  researchers drop the ball sometime when they reach world recognition ...they sometimes just waste away...because of their age may be ...and the truth remains hidden....We have to keep on going...more mysteries await...

Sunday, January 24, 2016

Perspective III

Folks don't let it pass, right now today: "Mars, Venus,Mercury, Saturn, Jupiter" are in Alignment in over 10 years, a rare phenomena in our skies...wake up and smell the coffee...It's going away before you know it...whether you like it or not.   It brings to mind an interesting dimension...indeed if you are in the lign how can you see this alignment...  well you are not in ligne so you can see it...  Same goes when you are looking at the Milky Way, or Galaxy, when you are in it...How can you see the Galaxy we are in!!!?  Well you can....I went to Florida few weeks ago at NASA.   There a 3D movie from the H. Telescope took me into the deep skies...And all was done, I was conquered!   Jupiter is the big one and it is visible!!!   I feel so small...insignificant  but deep in my mind I remember "we can change the world" but can we change the Universe...I think we do by sending all the I am told the Radioisotope battery can last 30 years...what picture will be sent back in 10,15 to be there to see it...Jupiter has few moons,  what are their effects on the they illuminate its nights, and why are they so many...These dimensions are still unknown to my knowledge...but tantalizing...

Saturday, January 23, 2016

perpective II

Folks  I say these events "stretch my mind"  it really does.  In fact it gets you tired and at the long run can get you depressed.  So your body defense mechanisms shut these things down.   You just forget about this and try to live your life.   And this makes life "livable".   We walk around "ignoring" major events in our surroundings immediate and extra-terrestrial.  Yes indeed, as you walk on the street, the sun continue to pull you in its travel, and Jupiter continue its walk around the sun and yet life continues whether you think about it or them (planets).   And since nothing is "still", the entire Galaxy must be moving around some other structure yet to be defined.   What we call Universe do exist.   Our shutting down to our surrounding actually protects us from having to worry about things.   Yes it would be heart breaking to always think we are going more than 60,000 miles /hour around the Sun.  Lets shut this down and comeback to earth...But on the other hand, this mechanism of shutting down things also affects us deeply as we become "shallow".   We don't think enough about things!  And we end up perceiving less.   Flying from one thing to another without depth...Say when you look at someone, you just say he is there and don't mind him, you stop looking at his eyes how deep his glance, what the color or his eyes, how log is his hair, the softness of his skin, what color is his cloth stopped deepening your thoughts about things and "shut these dimensions down that makes you human, an intelligent animal...So stop eluding the question and think about a dimension that is comfortable to your can go deep up or down...Downward, think of Human formed with systems, organs, and cells.  And within a cell, think of membranes, the Cytosol and the Nucleus, all formed by Molecules each with a function predetermined by their origin the DNA.   And each function make up the "human" functions and performances.   And each abnormality is encrypted.  This very thought will lead us to the construction of Medicine of tomorrow.   Yes Medicine of tomorrow will be completely "genetic".   Prepare ourselves to have a "gene" MicroChip.  Evidences have proven that what disease we have, are susceptible to and will develop in the future is encrypted in us, in our genes.   A Doctor will not do a thing without the exact knowledge of your genes.   We kept ignoring these facts and try to find a reason to escape this reality (cost of insurance, is it racial and so on) but cancer is pushing us to rethink this things.   Only targeting genes work efficiently.
How critical a gene makes the difference in outcome.   Discovering the PL-1 and Bruton (Activity of Ibrutinib) are a clear proof of the exercise.    Life tells us that things are not static...what happened when too much excitation of a receptor or lack thereof leads to is still understudy.   The constant persistance and performances of a living life continue to escape us...."don't shut down" now...

Wednesday, January 20, 2016


After a long pause due to disease-Prostate Cancer
It is time to return to writing blogs or actually continuing the long reflexion on life we lead.
Already I should be frank by announcing that my mind was literally "stretched" by new reflection about life and its several dimension.  I am in my late 50s and yet never thought about these truths as I do lately.  And quite frankly, I should confess that I am humbled by the truth and appreciate life even more now as I am struggling with these realities.

The first reality is the existence of the SUN.
did you know or realize the sun is 1.3 million times larger the Earth.   Not double, not time 10, 100 or a 1000, but 1.3 Million times larger than Earth.   This thing is Huge!!!!   And to look to us as it does, it is over 90 millions miles away.   Folks if you try to go there with modern devices, you will die before reaching this "thing", and that assuming you are not "melted" prior.  This SUN is so far that the sunlight that reaches us is 8 minutes old by the time we are "illuminated".  Folks the persecution of my mind does not stop here.   We (on earth) turn around the sun, and complete a full circle in 12 months.  to do that the earth has to travel at over 60,000 miles/hour.   The Earth will live on is a speedy vehicle around the sun at speed which blows my mind (not invented bu human).   There are more news...this immense sun is not alone in the Milky way.  There are billion of suns in our galaxy (Milky way).  And then there are many galaxies to stretch this (your minds) even more.

There are realities that are even closer,   away from the sun another planet is massively big called
Jupiter...probably 100 times bigger if my math is correct.  Perhaps another larger planet is SATURN.
This one is intriguing because it might have just wiped out the people if any who used to live there...And don't get excited let me explain.   Saturn is the only planet with surrounding ring made of "dust".   This dust is made of particles of several size including some that have 1 kilometer size...these things are spinning around Saturn...second fact is that Saturn is not completely if "hit" by something to change its if you go back to the disappearance of Dynosaurs, you found somewhere a "hit" theory where the earth was once completely covered by debris from a "hit" causing intense cold on earth...  Are these the same debris from hit on Saturn?
more mind stretching to come....

Thursday, March 26, 2015


We are back
after Robotic surgery
and 12 days of Intubation
which has left us deconditioned
Physical therapy is working with us
now I can write again
but my signature is still hard
already the literature has piled up
science continue to progress

Friday, February 6, 2015

Articles review

*Daratumumab added action to Revlimid and Decadron in Myeloma we are told!
*New important pathway :  The PLK1 disturbing spindle cell assemby...
*Blinatumomab, beneficial in refractory B cell precursor ALL....
*Potentiation of T cell  tumor recognition (of neoplastic transformation)
by  1.   Anti-CTLA4-----Ipilimumab
      2.   Anti-PD1----PEMBRO
      3.   CAR-T cell therapy
*Volarsetib in AML for older patient (research)
*Adding Everolimus to Taxol-Herceptin failed to increase disease free survival.   But it did in Her-2 negative front line!   a 7 months improvement was reported (20 Vs 13 months).  BOLERO-3 is talking!

Saturday, January 24, 2015

Cytokines and Vitamin D mysterious there a value in Cancers of the elderly!

"These sets of experiments establish clearly that combinations of recombinant cytokines and vitamins could induce substancial intramonocyte killing of M.Tuberculosis.   The mechanism involved in this killing activity is not clarified"

From M.Denis.
"Conclusions: our data imply that specific actions of 1,25 (OH) Vitamin D3 in Cytokine stimulated T-Cell functions could have a role in preventing T cells related autoimmune diseases but also predispose toward T-cell mediated allergic reactions"

        Ralph Thien  et al   (J Allergy Clin Immunol 2005;116:683-9.
F Focus on Iron,Selenium, Cupper, and Zinc
   Vitamin A  (mortality to infections),B (impacts on number of lymphocytes),C(phagocytosis),D(susceptibility in IL-6 
    diseases) ,E (dysfunction of T&B cells)   (Read Susanna Cunnigham-Rundles et al.

   When the age comes!