The only purpose of the cell is to survive, and to do so it has ability to not only live without resources or Oxygen for that matter for a while at least, through autophagia, the cell can live for a period of time without outside influx of nutrients. The cell can escape its environment to friendly shores, it can proliferate to increase the odds that at least one of the daughter cells can survive, through the years, the cell has learned to keep record of what mechanisms that helped it survive "bad weathers". It has build in Homeobox or Core binding Factors made of specific catalysts for only certain reactions and their determined sequence to orient the way metabolism should go. It has a wide variety of repair genes and regulators to temper rates of reactions and correct mistakes, It has a number of Paracrine or Autocrine secretions to maintain its growth (and this despite an incredible variety of Receptors and various exposures to a gamut of stimuli...One such paracrine and autocrine Molecule is: FGF2 which belong to the family of:
"Fibroblast growth factors, or FGFs, are a family of growth factors, with members involved in angiogenesis, wound healing, embryonic development and various endocrine signaling pathways. The FGFs are heparin-binding proteins and interactions with cell-surface-associated heparan sulfate proteoglycans have been shown to be essential for FGF signal transduction. FGFs are key players in the processes of proliferation and differentiation of wide variety of cells and tissues." wikipedia
FGF2 is a powerful defense against cellular death. It has been also accused of conferring resistance to chemotherapy. Through its link with JAK 2 which promotes it, FGF2 has risen to become one of the most formidable challenge to treating hematologic malignancies. It is reminiscent to IL-1, and its wound healing activities put it squarely at the FAK, its Heparan sulfate covered receptor is reminiscent of failing receptors of the triple negative Breast cancer. It confers Chemotherapy resistance such the one seen in Sarcoma,. Its angiogenesis activity put it in the metastatic cellular potentials. Its membrane localization put it closer to the Notch and Wnt. And has a growth factor and through the JAK-STAT, it has ample epigenetic consequences. FGF2, a Biomarker to deal with absolutely in the fight for the cure!
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