Multiple Sclerosis would fit

 Multiple sclerosis would fit the model of pathology prompted by failure at the receptor of Interleukins
with resulting increase of Cytokines.  In this model the initial insult will be destruction of Glycans at the IL-2,7 receptor resulting in the increase of these cytokines.  Although they will fail at the receptors, they will still attract T cell and other relevant inflammatory cell.  This is confirmed by the scenario of Traumatic brain injury in which lack of post-synaptic stimulation also result in post synaptic neuron destruction.   Failure at the receptors stays the most dangerous cellular event.   The triple negative Breast cancer is another example.
The effect of Interferon as a therapeutic intervention confirms that increase of Interleukins is the most significant driving event in the disease!  It is driving even the coexisting gliosis found in the disease...