The trenches of stress

Whether the stimuli to stress be physical (heat, radiation, cold etc) or autoimmune or infectious(Interleukins, TNF,other cytokines and cyclins, etc.).deep into the "bowel" of the cell these events have a chemical effect involving genes that are also involved in proliferation, amplification, cellular differentiation, division etc.   Cellular stress potentially could lead to Apoptosis. Therefore anti-apoptotic genes are also stimulated to stop the cell from dying from a "benign and non overwhelming " stress.  Anti-Apoptotic genes include those that directly stops Apoptosis from Happening (GADD45, MyD118, Ing1p33inca etc) but also those involved in DNA repair XRCC1, PARP1,2,APEX1,PCNA.

• APEX1,^[4]
• APTX,^[5][6]
• OGG1,^[7]
• PARP2,^[8]
• PCNA,^[9]
• PNKP,^[10][11]
• POLB,^{[12][9][13][14]} and
• PARP1.^{[6][15]wikipedia} 
•  PCNA has been shown to interact with Ku70,^[13][14] MSH3,^[13][15][16] Werner syndrome ATP-dependent helicase,^[17][18] RFC2,^[13][19][20] RFC3,^[13][21] RFC1,^{[13][22][23][24][25]} RFC4,^[13][19] RFC5,^[13][19][24] GADD45G,^[26][27] CDC25C,^[28] MUTYH,^[29] Flap structure-specific endonuclease 1,^{[30][31][32][33][34][35][36]} Cyclin O,^[13][37] CHTF18,^[13] Y box binding protein 1,^[38] Cyclin D1,^[39][40] Annexin A2,^[13] MSH6,^[13][15][16] DNMT1,^[41][42][43] HDAC1,^[44] KCTD13,^[45] XRCC1,^[46] Cyclin-dependent kinase 4,^[40][47] Ku80,^[13][14][48] HUS1,^[49] GADD45A,^{[50][51][52][53][54]} POLD2,^[55] ING1,^[56] POLH,^[57] KIAA0101,^[36] POLDIP2,^[58] EP300,^[59] MCL1,^[60] POLD3,^[13][61] Cyclin-dependent kinase inhibitor 1C,^[62] POLL,^[63][64][65] Ubiquitin C^[66][67][68] and P21.^{[23][32][36][62][69][70][71][72]wikipedia}
•  
•     DNA damage repair and those involved in containment of Oxidative attacks are very much part of genetic coping mechanisms against stress induced damages to the cell.   Suffice is to say that these events are epigenetic and will also involve the MeCTR and DNMT1 as mentioned above.

Dealing with stress is very much molecular at cell level!
of note, this section identify PCNA, a series of polymerase cofactor enzymes/proteins, as an important target for intervention!and Ing1 protects against UV induced Apoptosis per researchers!