Genes involved in stressful events

PATTERNS OF STRESS

It is by now evident that there is multiple types of stress
all of which have different genetic basis
The variety of stresses seems mostly determined by stimuli inducing them.
Indeed stress induced by an a new infection is different than that induced by a stressful job interview. Stress leading to a constant level of subluminal anxiety seems to be the most life threatening as it stimulate a set of of genes that are either directly linked to survival or secondary linked to its pathway.
globally, No stress is the same.
Various stresses:
1.stress due to an interview
2.stress due to pressure of a deadline
3. stress due to an undefined fear
4.stress due to an infection
5.stress imposed by immunization to our systems
6.the Somogyi effect
7. fear and flight reaction
8.stress imposed by hard jobs, "needed but not liked" jobs, tasks, or bosses (and some times spouses).
9.Stress imposed by inflammatory bowel diseases or autoimmune syndromes!stress of chronic diseases (Obesity, Hypertension, etc.) and other non curable diseases
etc.
our abilities to cope
the sudden or length nature and duration of the stimuli,
acknowledging the stress
our response to the stress and whether or ot we achieve complete or partial remission to the stress
all these factors impact both short and long term consequences of stress in our systems.
MOST IMPORTANTLY AS FAR AS OUR SURVIVAL IS CONCERNED, THE GENES SOLICITED DURING AND AFTER THE EVENT/STIMULI ARE CLEAR DETERMINANTS AND MOST IMPORTANT FOR LONG TERM OUTCOME.

GENES INVOLVED IN  STRESSES
=========================
Depending on the sudden-acuteness or chronicity of the stimuli, we use various genes.  There are genes involved in immediate reaction to the stimuli, genes due to receptor-stimuli interactions,  pathways elicited whether necessary or not, downstream consequences of elicited pathways, and of course cycline effects as a result.  Hormonal involvement is often part or the initial stimulation, but other hormone disturbances are a result of persistent cyclins'effects.  Mechanisms of coping include not only genes meant to provide us potential to process and adjust to the stimuli, but also pre-printed patterns in the epigenetic zone, and ratios of hormones which prone us to coping evenly and sanely to the stimuli.

The importance of the nature of stimulation cannot be "stressed" enough.

ie. when the stress is an autoimmune disease, the role of TNF, and TGF cannot be over-emphasized,
ie. when it is an infection, although TNF and TGFs play an important role, Cyclins (IL-1, IL-6, 10,12,13 and even 23) comes into play.  (remember the protective IL-4)
ie. sudden inducing fear events stimulate the fear and flight reaction (Adrenaline, noradrenaline,steroids(including the Androgen receptor gene) and even somatostatins and other GI "Enterokines"  etc).
In the Brain, Oxycytosin, serotonin, and other neuro-factors (BDNF).
It cannot be a surprise that Hypertension will involve vasopressin, neurotensin
and some stimuli will involve IGF-1, PON-1,PR4 like genes and ATF4, to list just a few genes!
It is interesting that genes involved in stress management not only include the NF-kB but genes known to immunize or protect good cells from chemotherapeutic drugs!
The critical involvement of Actin-dependent pathways is worth being noted!
Mitochondrial glycolytic and Oxidative participation is very much related to the nature of the stimuli...and so is the MTOR participation which way heavily on survival impact!

full list of genes to follow!