Monday, May 26, 2014

Case in point : Urothelial Cancer with plasmacytoid histology

>the tumor is bad news
1.It is Multicentric, Multifocal, and therefore metastatic at time of diagnosis
2.Its signet rings characteristic has deep meaning and may have had something to do with its tolerance by the body and metastatic or invasiveness. (and dyscohesive or non cohesive nature of cells at morphology of cell suggestive of Micro-environment corruption)
3.plasma cell characteristic "CD138"
4.secretion of Validated Biomarkers CA 19-9 and Beta-HCG
5.response to Platinun based regimen (Bladder---Gem-Cisp Vs GI origin---EOX)
6. Affect the young maximizing life loss
7.poor prognosis outlook
8.Wang et al. "The immunohistochemical profiles of the tumour cells were focal positive for E-cd, PCK, EMA, CAM5.2, CK7, CD138, AE1/AE3, and CK20, but negative for LCA, Vim, and S-100."
9.Nabbout et al:" After receiving 6 cycles of neoadjuvant chemotherapy (epirubicin, oxaliplatin, capecitabine), the lesions responded well and the patient underwent a complete gastrectomy with jejunoesophageal anastomosis."

The tumor current evaluation rarely include gene evaluation and therefore is inadequate.

by producing CA19-9 proximity to Pancreatic cancer is unquestionable
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