Monday, May 5, 2014

Lung Cancer detection Going back to Basic!

Our study on lung cancer detection got boosted by UTEP individual efforts, indeed the availability of some Antibodies to certain genes allowed the crew led by DR Chai to screen sera of lung cancer patients for these molecules.  This extra efforts allowed us to identify Cyclin B1, NPM1, and 8 other antibodies at various quantities.   Suffice is to add that Cyclin B1 was found more frequently in 26 % of patients.  We have discussed NPM1 briefly in other blog.  But the confirmation of the presence of Cyclin B1 again point to the point that a number of molecular transformations will be occurring once the neoplastic process is underway early in the cascade of cellular events.

One of the first event after the neoplasm is engaged, most likely cigarette induced MDM2 driven changes, is that mitosis should be the general orientation of the now proliferating malignant cell.  And Cyclin B1 does this by committing the cell to cancerous proliferation.   With Cyclin B1 increased, the cancerous cell is squarely turned to changes favoring division and proliferation.  Protection of the Nucleus for chromosomes is broken down to allow spindle formation, this is achieved through Cyclin B1.  Clearly under Cyclin B1 cellular division goes wild and natural stops of this process by the APC gene is removed by the shutting down of the Mitosis exit door!

Other gene interacting with Cyclin B1 will engage P53, p38/JNK, MAPK and even the stress related HSP genes.  Through CRK, the Reeling and DABK1 is not far behind!
Another observation was a Koc gene amplification.  This is another finding pointing to cancer underway.  Here again certain RNA need to be shut down to  and our friend Koc will do that!   This is an attempt to stream line the activities.

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