Saturday, May 10, 2014

NOTES FROM SAN DIEGO -PANCREATIC CANCERS

*NO NEWS IN PANCREATIC CANCERS

It is increasingly evident that 4 options are offered in Pancreatic cancers
1-Folforinox, the best regimen offered in the young and great performance
with real improvement in Response rates and survival benefit
2.But in elderly and patients with poorer performance status, Abraxane 125mg/m2 + Gemzar1000mg/m2 weekly x3 Q4weeks offers the best alternative.

with survival data
(compared Gemzar alone)
----------------------------
    1 year  35 %  Vs    25%
   2years 10%   Vs   6%
   3years   4 %  Vs   0

(take these data with caution)
with Abraxane combination better tolerated than Folforinox
3. Gemzar +Tarceva still an option
4. Gemzar alone, basically no longer an option given the tolerability of Abraxane -Gemzar and its superiority!  unless you are desperate!

CAUTION IN THE FUTURE THEY MAY BE GENETIC BIOMARKERS TO HELP DETERMINE WHAT OF THE 2 (FOLFORINOX vS ABRAXANE-GEMZAR)

WITH ABRAXANE -GEMZAR FOR TUMOR WITH (SPARC,RRMM,hEMT1)

WITH FOLFIRI (TOP1,ERCC1,THYMIDILATE SYNTHASE (TS))

(THESE ARE PERSONAL NOTES AND MAY BE MISTAKEN)
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