How about "Embryonal" and "Blastic appearance" inside information

*According to Perez Moreno et al....E2A works in the depression of E-cadherin
a phenomena which intervene in the metastasis of cancer...is fair to conclude the Blocking E2A could decrease metastatic potential of cancers?
*Depression of E-Cadherin may also play a role in Epithelial mesengial transformation or transition, a phenomena that seems to occur early in the neoplastic transformation, could blocking E2A be used in cancer prevention?
*does the embryonal or blastic appearance is linked to the over expression of the HOXb1 and family
or is it linked to the overexpression of PBX1

Memorable  possible intricacy
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 (TCF3)               !-  HOXb1------E-Cadherin
*E2A---PBX1---!-  MEIS-1-----MLL+PAF----TET1---c-MYB
      !                     !-  HOXs
      !
CBP/p300----TWIST-1
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what about SRG3?  what do we know?"SRG3 (Smarcc1) is a core subunit of the SWI/SNF complex. In the absence of SRG3, embryonic development ceases during peri-implantation stages," ncbi! could intervene in differentiation arrest?
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The MEK must be somewhere, and Rho gene!
ARE THESE POTENTIAL TARGETS?

THE HOXS ARE STANDING OUT!