MICROSATELLITE INSTABILITY IN TRIPLE NEGATIVE BREAST CANCER?.

One will not think of this normally, but because of its good prognosis a biomarker, and because of its positive predictive value in terms of response to therapy, One may want to know its participation if any or share in triple negative breast cancer.
Microsatellite instability is almost standard of care a request in Colorectal cancer as it has entered the ASCO and NCCN guidelines.   But is it exclusive to COLORECTAL cancers.

' Lynch syndrome (HNPCC or Hereditary nonpolyposis colorectal cancer ) is an autosomal dominant genetic condition which has a high risk of colon cancer^[1] as well as other cancers including endometrium, ovary, stomach, small intestine, hepatobiliary tract, upper urinary tract, brain, and skin. The increased risk for these cancers is due to inherited mutations that impair DNA mismatch repair.'

This definition clearly exclude Breast Cancer however it would be of clinic interest to test triple negative breast cancer for these features in trying to further define the various group of this condition.  Likelihood of finding anything is low. But may be we can find a cohort, a subtype that we can declare of good prognosis?