1. ZWINT:
During cell division, separation of chromosome or chromosome movement is not random, and follows microtubule tracks through an attachment at the Kinetochore. Kinetochore attaches the chromosome at its inner section, and the micotubule at the outer section. protein components of the the Kinetochore include Dynein, a cytoplasmic protein that need to be recruited (phosphorylated) to the Kinetochore. The ZWINT (at 10q21)with its interactor ZW10, serves as a substrate to AURORA B, helps globally with the Dynein recruitment at the Kinetochore. Disruption at the Kinetochore will foil cell division.
Expression of the ZWINT marks a proliferative phase in the cancerous process.
2. TTK
CANNOT DESCRIBE IT BETTER
"
- This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication. It has been found to be a critical mitotic checkpoint protein for accurate segregation of chromosomes during mitosis. Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009]
Genomic context
- Location :
- 6q13-q21"
- SOURCE NCBI
- ------------------------------
- RELATED GENES : THE CYCLIN DEPENDENT KINASE AND PLK-1
- RELATED PATHWAY pRb PATHWAY.
- THIS IS PROLIFERATION AT IT BEST, CANCER MUTATES THESE TO ESCAPE PROLIFERATION CONTROL
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