NOMENCLATURE OF GENES DISCUSSED IN THE 3RD LAW (CONTINUED)

5. E2F1  VERY IMPORTANT GENE
ITS PROTEIN PROMOTES CD2AP TO AFFECT T CELL FUNCTION AND FUNCTION OF PODOCYTES, DISTURBANCE THEREFORE WILL AFFECT THE KIDNEY IN THE HOST.
IT IS REPRESSED BY THE RETINOBLASTOMA PROTEIN AND LEAD TO SENESCENECE
WHEN INVOLVED IN THE CDK1 PATHWAYS IT IS ALSO REPRESSED.   IT IS A VERSATILE GENE OF WHICH PROTEIN IMPORTANT IN CELL CYCLE HAS FUNCTION VARYING WITH ITS POSITION. IT IS KNOWN TO BE AT THE ESTROGEN RECEPTOR.

YOU CANNOT TARGET THIS GENE AND COME UP EMPTY.  HMGA GENE INCREASES THIS E2F1. IT HAS INTERACTION WITH SENESCENT CHROMATIN.

6. GEMININ

In Mitosis

During mitosis or M phase, geminin stabilizes the replication factor Cdt1 by protecting it from ubiquitination and therefore subsequent proteolysis, thereby potentially promoting DNA replication during the following cell cycle. Although inhibition of geminin by RNAi leads to destabilization of Cdt1 protein and impairment of DNA replication during the following cell cycle in many cancer cell lines, no such cell cycle defect is seen in primary and immortalized cell lines (although Cdt1 levels are still reduced in these cells).^[5]
Geminin therefore is an important player in ensuring that one and only one round of replication occurs during each cell cycle. (WIKIPEDIA)