WHAT IS A DRIVER MUTATION ANYWAY?

In a cell, there are aberrancies which are bound to happen during cell division that are not critical cell functions and get by like any heterogeneity in our genes.  These aberrancies with no impact in cell survivors are some time called or includes the "passenger" Mutations. life follows a flow of forces which, when unhindered, keeps living cells going strong.  Until an alteration occurs affecting one pathways that belong to this main flow of force without clearly stopping it but causing enough distorsion to detour its normal evolution.
Such an alteration is driver mutation.
The effect of a driver mutation can be a stoppage in Maturity or acquisition of new capability while maintaining survival.  It could be a loss of restrain or an unwelcome augmentation of autocrine function,  A stimulation of enzymatic processes release at a promoter gene.  All these scenarios depict a driver Mutation.
Our current standard of defining a Driver Mutation is not only linked to finding a Mutation (testing for EGFR, KRAS, BRAF and HER-2 in lung cancer) but also by weighing therapeutic response to selected target therapy.    So if you find EGFR and gave related medication, you get a response. You conclude that EGFR was a driver.   This kind of conclusion however leaves room to the fact that an overwhelming action can move things along without it being a driver.
We have to have more information.   Finding a mutation could imply it is active or it may not.   We need to dig deeper.  Does it overwhelmingly stimulate other pathways?  Does it induces more transcription factors more enzymes, more regulator proteins etc...

Gene sequencing of certain Axons has so far been great at finding Mutation,  let's find better ways to gauge intensity of pathways and gene transcription to further define our "Drivers".