Sunday, April 27, 2014

OUR OLD EXPERIENCE HELPS ! LAS VEGAS ROCKS!

Yes as a drug gains more indications, the past experience makes it easier for Oncologist practitioner to re-use drugs they have been used to!
For Hepatocellular Carcinoma, the drug on the mind of all oncologists is NEXAVAR, yeah, we have been accustomed to managing its rashes and Diarrhea, and watch its marrow suppression.  A combination of weekly visits and then monthly for our patients to start with!
Well it is the same dance once again in Metastatic thyroid cancer, the kind of Metastatic progressing and resistant to Iodine based treatments!   NFX1 OR SHOULD WE SAY
 NBCI-gene "Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth.'
Jing Du et al:"Correlation analysis revealed that there was a positive relationship between the level of HPV16 E7 and the expression of p65. The correlation between E7 and p53 was also significant, although to a lesser degree"
IT'S NOT JUST P65, BUT P300, P25
AND THE NOTCH1 IS NOT FAR ! MEANING VEGF-A-DELTA,JAGGED1,AND A SLEW OF
MIR (s) AND SF3Bs, NOT TO MENTION TENACIN AND CADHERINS!
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