Thursday, April 10, 2014

search for the "OBLONG" pill.

"Oblong man" rather than "circle man" infers less obesity
Obesity is a growing issue in the United States and many want to find an answer to obesity by coming up with a "pill" that will make people lose weight...the "Oblong Pill" is such a pill.
while many reports "fighting" against obesity, few patients with autoimmune diseases are reporting to us for inability to gain weight!  In Autoimmune diseases, we surmise that cytokines induced in this disease significant perturbation of both glucogenesis and lipogenesis-lysis.  The logical conclusion is that isolating the cytokines involved may help with weight management.  But in autoimmune disease we could also localize relevant biomarkers that mark the increase in cytokines.   We could also test why cellular proliferation does not occur (is it through FOXO3), and measure transformation in lymphoproliferative disorders (is it through the LYN, RELA etc?). Should we avoid these types of development and what would be the type of warning that these mechanisms are elicited .

Bani-Sadr et al "Weight loss is reported by more than 20% of hepatitis C virus (HCV)-monoinfected patients treated with the peg-interferon (peg-IFN) and ribavirin combination."  and indeed chronic use of interferon is accompanied by weight loss.  Interferon belong to the Cytokines, another proof that Cytokine may be an answer to Obesity if controlled and managed carefully!

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